Multiple dynamic representations in the motor cortex during sensorimotor learning

D. Huber, D. A. Gutnisky, S. Peron, D. H. O'Connor, J. S. Wiegert, Lin Tian, T. G. Oertner, L. L. Looger, K. Svoboda

Research output: Contribution to journalArticle

259 Citations (Scopus)

Abstract

The mechanisms linking sensation and action during learning are poorly understood. Layer 2/3 neurons in the motor cortex might participate in sensorimotor integration and learning; they receive input from sensory cortex and excite deep layer neurons, which control movement. Here we imaged activity in the same set of layer 2/3 neurons in the motor cortex over weeks, while mice learned to detect objects with their whiskers and report detection with licking. Spatially intermingled neurons represented sensory (touch) and motor behaviours (whisker movements and licking). With learning, the population-level representation of task-related licking strengthened. In trained mice, population-level representations were redundant and stable, despite dynamism of single-neuron representations. The activity of a subpopulation of neurons was consistent with touch driving licking behaviour. Our results suggest that ensembles of motor cortex neurons couple sensory input to multiple, related motor programs during learning.

Original languageEnglish (US)
Pages (from-to)473-478
Number of pages6
JournalNature
Volume484
Issue number7395
DOIs
StatePublished - Apr 26 2012
Externally publishedYes

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Motor Cortex
Learning
Neurons
Vibrissae
Touch
Motor Neurons
Sensory Receptor Cells
Population

ASJC Scopus subject areas

  • General

Cite this

Huber, D., Gutnisky, D. A., Peron, S., O'Connor, D. H., Wiegert, J. S., Tian, L., ... Svoboda, K. (2012). Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature, 484(7395), 473-478. https://doi.org/10.1038/nature11039

Multiple dynamic representations in the motor cortex during sensorimotor learning. / Huber, D.; Gutnisky, D. A.; Peron, S.; O'Connor, D. H.; Wiegert, J. S.; Tian, Lin; Oertner, T. G.; Looger, L. L.; Svoboda, K.

In: Nature, Vol. 484, No. 7395, 26.04.2012, p. 473-478.

Research output: Contribution to journalArticle

Huber, D, Gutnisky, DA, Peron, S, O'Connor, DH, Wiegert, JS, Tian, L, Oertner, TG, Looger, LL & Svoboda, K 2012, 'Multiple dynamic representations in the motor cortex during sensorimotor learning', Nature, vol. 484, no. 7395, pp. 473-478. https://doi.org/10.1038/nature11039
Huber D, Gutnisky DA, Peron S, O'Connor DH, Wiegert JS, Tian L et al. Multiple dynamic representations in the motor cortex during sensorimotor learning. Nature. 2012 Apr 26;484(7395):473-478. https://doi.org/10.1038/nature11039
Huber, D. ; Gutnisky, D. A. ; Peron, S. ; O'Connor, D. H. ; Wiegert, J. S. ; Tian, Lin ; Oertner, T. G. ; Looger, L. L. ; Svoboda, K. / Multiple dynamic representations in the motor cortex during sensorimotor learning. In: Nature. 2012 ; Vol. 484, No. 7395. pp. 473-478.
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