Multiple Autoantibodies in Patients with Silicone Breast Implants

E. Bar-Meir, Suzanne S Teuber, H. C. Lin, I. Alosacie, G. Goddard, J. Terybery, N. Barka, B. Shen, J. B. Peter, M. Blank, M. Eric Gershwin, Y. Shoenfeld

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Abstract

Diverse immunologic abnormalities have been described in women who received silicone breast implants. However, most studies have focused on either a limited number of patients or a small panel of autoantibodies. We report the analysis of 20 autoantibodies in 116 women with implants and 134 controls. The patients ranged from 26- to 66-years-old, with a mean of 45.7±8.3 years; breast prostheses were in place for a mean of 15±5.6 years, with a range of 4 to 30. The chief complaints of the 116 patients included polyarthralgias, fatigue, myalgias, morning stiffness, and decreased memory. All 250 sera were tested blindly using a panel of 20 autoantigens including SS-A, SS-B, RNP, cardiolipin (CL), collagen types I, II and IV, phosphatidylserine (PS), myeloperoxidase (MPO), sulfatides (sulf), thyroglobulin (TG), gangliosides (GDIa; GM2), proteinase-3 (PR3), Jo-1, Sm, HPRPP-ribosomal phosphate, histones (H2AH2B), Scl-70 and glomerular basement membrane (NC-1). Values from individual patients were considered positive only when greater than 3 SD above the control mean. There was a statistically significant greater frequency of autoantibodies in women with implants for 15 of the 20 autoantigens; these were particularly striking for anti-H2AH2B, HPRPP, SS-A, SS-B, Scl-70, CL, PS, GM2, and NC-1. Many patients harbored several autoantibodies; 20% had four autoantibodies; 8% had six autoantibodies. The association of autoantibodies and implants suggests an adjuvant action of silicon/silicone byproducts.

Original languageEnglish (US)
Pages (from-to)267-277
Number of pages11
JournalJournal of Autoimmunity
Volume8
Issue number2
DOIs
StatePublished - Apr 1995

Fingerprint

Breast Implants
Silicones
Autoantibodies
Cardiolipins
Phosphatidylserines
Autoantigens
G(M2) Ganglioside
Myeloblastin
Sulfoglycosphingolipids
Glomerular Basement Membrane
Collagen Type IV
Collagen Type II
Thyroglobulin
Myalgia
Arthralgia
Silicon
Collagen Type I
Histones
Peroxidase
Prostheses and Implants

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Bar-Meir, E., Teuber, S. S., Lin, H. C., Alosacie, I., Goddard, G., Terybery, J., ... Shoenfeld, Y. (1995). Multiple Autoantibodies in Patients with Silicone Breast Implants. Journal of Autoimmunity, 8(2), 267-277. https://doi.org/10.1006/jaut.1995.0020

Multiple Autoantibodies in Patients with Silicone Breast Implants. / Bar-Meir, E.; Teuber, Suzanne S; Lin, H. C.; Alosacie, I.; Goddard, G.; Terybery, J.; Barka, N.; Shen, B.; Peter, J. B.; Blank, M.; Gershwin, M. Eric; Shoenfeld, Y.

In: Journal of Autoimmunity, Vol. 8, No. 2, 04.1995, p. 267-277.

Research output: Contribution to journalArticle

Bar-Meir, E, Teuber, SS, Lin, HC, Alosacie, I, Goddard, G, Terybery, J, Barka, N, Shen, B, Peter, JB, Blank, M, Gershwin, ME & Shoenfeld, Y 1995, 'Multiple Autoantibodies in Patients with Silicone Breast Implants', Journal of Autoimmunity, vol. 8, no. 2, pp. 267-277. https://doi.org/10.1006/jaut.1995.0020
Bar-Meir, E. ; Teuber, Suzanne S ; Lin, H. C. ; Alosacie, I. ; Goddard, G. ; Terybery, J. ; Barka, N. ; Shen, B. ; Peter, J. B. ; Blank, M. ; Gershwin, M. Eric ; Shoenfeld, Y. / Multiple Autoantibodies in Patients with Silicone Breast Implants. In: Journal of Autoimmunity. 1995 ; Vol. 8, No. 2. pp. 267-277.
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