Multiparametric optical coherence tomography imaging of the inner retinal hemodynamic response to visual stimulation

Harsha Radhakrishnan, Vivek Srinivasan

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

The hemodynamic response to neuronal activation is a well-studied phenomenon in the brain, due to the prevalence of functional magnetic resonance imaging. The retina represents an optically accessible platform for studying lamina-specific neurovascular coupling in the central nervous system; however, due to methodological limitations, this has been challenging to date. We demonstrate techniques for the imaging of visual stimulus-evoked hyperemia in the rat inner retina using Doppler optical coherence tomography (OCT) and OCT angiography. Volumetric imaging with three-dimensional motion correction, en face flow calculation, and normalization of dynamic signal to static signal are techniques that reduce spurious changes caused by motion. We anticipate that OCT imaging of retinal functional hyperemia may yield viable biomarkers in diseases, such as diabetic retinopathy, where the neurovascular unit may be impaired.

Original languageEnglish (US)
Article number086010
JournalJournal of Biomedical Optics
Volume18
Issue number8
DOIs
StatePublished - Aug 1 2013

Fingerprint

hemodynamic responses
Photic Stimulation
Optical tomography
Optical Coherence Tomography
Hemodynamics
stimulation
retina
tomography
Hyperemia
Imaging techniques
Retina
visual stimuli
three dimensional motion
central nervous system
Angiography
Three-Dimensional Imaging
angiography
biomarkers
Neurology
Biomarkers

Keywords

  • angiography
  • Doppler
  • hemodynamics
  • neurovascular coupling
  • ophthalmology
  • optical coherence tomography
  • retina

ASJC Scopus subject areas

  • Biomedical Engineering
  • Biomaterials
  • Electronic, Optical and Magnetic Materials
  • Atomic and Molecular Physics, and Optics
  • Medicine(all)

Cite this

Multiparametric optical coherence tomography imaging of the inner retinal hemodynamic response to visual stimulation. / Radhakrishnan, Harsha; Srinivasan, Vivek.

In: Journal of Biomedical Optics, Vol. 18, No. 8, 086010, 01.08.2013.

Research output: Contribution to journalArticle

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