Multiorgan procurement does not affect the immediate outcome of kidney transplants

P. H. Morel, Christoph Troppmann, P. S. Almond, R. Schlumpf, K. J. Gillingham, D. E R Sutherland, D. L. Dunn, W. D. Payne, A. J. Matas, J. S. Najarian

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The increasing number of organs required for transplantation has given an impetus to the development of techniques of multiorgan procurement from a single cadaver donor. We studied the effect of these techniques on the short-term outcome of kidney transplants. Between 1.1985 and 12.1989, 168 kidneys were procured by our team during multiorgan harvests, 166 of which were transplanted in our institution or elsewhere. Follow-up could be obtained for 161. The pancreas was retrieved simultaneously in 14 cases (9%); the pancreas and the liver in 34 (21%); the pancreas, the liver, and the heart in 73 (45%); the pancreas, the liver, the heart and the lungs in 24 (15%); the pancreas and the heart in 4 (2%), and the pancreas, the heart and the lungs in 2 (1%). We have incomplete information for 10 kidneys (7%). Immediate graft function occurred in 125 grafts (78%) (Group I); 31 kidneys (19%) had delayed graft function (DGF), 4 (2%) had technical failure (TF) (thrombosis), and 1 (1%) was a primary nonfunction (PNF) (Group II). Comparison with historical controls suggests that multiorgan retrieval had no impact on the incidence of DGF. Multivariate analysis demonstrated that the determinant factor in immediate graft function was the length of preservation 20 ± 8 hours for Group I vs 26 ± 8 for Group II. Patients with DGF had normal creatinine values at 3 and 6 months, similar to those with immediate function. We conclude that the combined simultaneous procurement of the kidney and other organs does not affect the outcome of the kidney transplant. DGF is related to perservation time.

Original languageEnglish (US)
Pages (from-to)381-385
Number of pages5
JournalClinical Transplantation
Volume5
Issue number5
StatePublished - 1991
Externally publishedYes

Fingerprint

Delayed Graft Function
Pancreas
Transplants
Kidney
Liver
Lung
Organ Transplantation
Cadaver
Creatinine
Reference Values
Thrombosis
Multivariate Analysis
Tissue Donors
Incidence

Keywords

  • Kidney function
  • Kidney transplantation
  • Organ procurement

ASJC Scopus subject areas

  • Immunology
  • Transplantation

Cite this

Morel, P. H., Troppmann, C., Almond, P. S., Schlumpf, R., Gillingham, K. J., Sutherland, D. E. R., ... Najarian, J. S. (1991). Multiorgan procurement does not affect the immediate outcome of kidney transplants. Clinical Transplantation, 5(5), 381-385.

Multiorgan procurement does not affect the immediate outcome of kidney transplants. / Morel, P. H.; Troppmann, Christoph; Almond, P. S.; Schlumpf, R.; Gillingham, K. J.; Sutherland, D. E R; Dunn, D. L.; Payne, W. D.; Matas, A. J.; Najarian, J. S.

In: Clinical Transplantation, Vol. 5, No. 5, 1991, p. 381-385.

Research output: Contribution to journalArticle

Morel, PH, Troppmann, C, Almond, PS, Schlumpf, R, Gillingham, KJ, Sutherland, DER, Dunn, DL, Payne, WD, Matas, AJ & Najarian, JS 1991, 'Multiorgan procurement does not affect the immediate outcome of kidney transplants', Clinical Transplantation, vol. 5, no. 5, pp. 381-385.
Morel PH, Troppmann C, Almond PS, Schlumpf R, Gillingham KJ, Sutherland DER et al. Multiorgan procurement does not affect the immediate outcome of kidney transplants. Clinical Transplantation. 1991;5(5):381-385.
Morel, P. H. ; Troppmann, Christoph ; Almond, P. S. ; Schlumpf, R. ; Gillingham, K. J. ; Sutherland, D. E R ; Dunn, D. L. ; Payne, W. D. ; Matas, A. J. ; Najarian, J. S. / Multiorgan procurement does not affect the immediate outcome of kidney transplants. In: Clinical Transplantation. 1991 ; Vol. 5, No. 5. pp. 381-385.
@article{afc4f95bc9b84371ac665fb35bf51ad4,
title = "Multiorgan procurement does not affect the immediate outcome of kidney transplants",
abstract = "The increasing number of organs required for transplantation has given an impetus to the development of techniques of multiorgan procurement from a single cadaver donor. We studied the effect of these techniques on the short-term outcome of kidney transplants. Between 1.1985 and 12.1989, 168 kidneys were procured by our team during multiorgan harvests, 166 of which were transplanted in our institution or elsewhere. Follow-up could be obtained for 161. The pancreas was retrieved simultaneously in 14 cases (9{\%}); the pancreas and the liver in 34 (21{\%}); the pancreas, the liver, and the heart in 73 (45{\%}); the pancreas, the liver, the heart and the lungs in 24 (15{\%}); the pancreas and the heart in 4 (2{\%}), and the pancreas, the heart and the lungs in 2 (1{\%}). We have incomplete information for 10 kidneys (7{\%}). Immediate graft function occurred in 125 grafts (78{\%}) (Group I); 31 kidneys (19{\%}) had delayed graft function (DGF), 4 (2{\%}) had technical failure (TF) (thrombosis), and 1 (1{\%}) was a primary nonfunction (PNF) (Group II). Comparison with historical controls suggests that multiorgan retrieval had no impact on the incidence of DGF. Multivariate analysis demonstrated that the determinant factor in immediate graft function was the length of preservation 20 ± 8 hours for Group I vs 26 ± 8 for Group II. Patients with DGF had normal creatinine values at 3 and 6 months, similar to those with immediate function. We conclude that the combined simultaneous procurement of the kidney and other organs does not affect the outcome of the kidney transplant. DGF is related to perservation time.",
keywords = "Kidney function, Kidney transplantation, Organ procurement",
author = "Morel, {P. H.} and Christoph Troppmann and Almond, {P. S.} and R. Schlumpf and Gillingham, {K. J.} and Sutherland, {D. E R} and Dunn, {D. L.} and Payne, {W. D.} and Matas, {A. J.} and Najarian, {J. S.}",
year = "1991",
language = "English (US)",
volume = "5",
pages = "381--385",
journal = "Clinical Transplantation",
issn = "0902-0063",
publisher = "Wiley-Blackwell",
number = "5",

}

TY - JOUR

T1 - Multiorgan procurement does not affect the immediate outcome of kidney transplants

AU - Morel, P. H.

AU - Troppmann, Christoph

AU - Almond, P. S.

AU - Schlumpf, R.

AU - Gillingham, K. J.

AU - Sutherland, D. E R

AU - Dunn, D. L.

AU - Payne, W. D.

AU - Matas, A. J.

AU - Najarian, J. S.

PY - 1991

Y1 - 1991

N2 - The increasing number of organs required for transplantation has given an impetus to the development of techniques of multiorgan procurement from a single cadaver donor. We studied the effect of these techniques on the short-term outcome of kidney transplants. Between 1.1985 and 12.1989, 168 kidneys were procured by our team during multiorgan harvests, 166 of which were transplanted in our institution or elsewhere. Follow-up could be obtained for 161. The pancreas was retrieved simultaneously in 14 cases (9%); the pancreas and the liver in 34 (21%); the pancreas, the liver, and the heart in 73 (45%); the pancreas, the liver, the heart and the lungs in 24 (15%); the pancreas and the heart in 4 (2%), and the pancreas, the heart and the lungs in 2 (1%). We have incomplete information for 10 kidneys (7%). Immediate graft function occurred in 125 grafts (78%) (Group I); 31 kidneys (19%) had delayed graft function (DGF), 4 (2%) had technical failure (TF) (thrombosis), and 1 (1%) was a primary nonfunction (PNF) (Group II). Comparison with historical controls suggests that multiorgan retrieval had no impact on the incidence of DGF. Multivariate analysis demonstrated that the determinant factor in immediate graft function was the length of preservation 20 ± 8 hours for Group I vs 26 ± 8 for Group II. Patients with DGF had normal creatinine values at 3 and 6 months, similar to those with immediate function. We conclude that the combined simultaneous procurement of the kidney and other organs does not affect the outcome of the kidney transplant. DGF is related to perservation time.

AB - The increasing number of organs required for transplantation has given an impetus to the development of techniques of multiorgan procurement from a single cadaver donor. We studied the effect of these techniques on the short-term outcome of kidney transplants. Between 1.1985 and 12.1989, 168 kidneys were procured by our team during multiorgan harvests, 166 of which were transplanted in our institution or elsewhere. Follow-up could be obtained for 161. The pancreas was retrieved simultaneously in 14 cases (9%); the pancreas and the liver in 34 (21%); the pancreas, the liver, and the heart in 73 (45%); the pancreas, the liver, the heart and the lungs in 24 (15%); the pancreas and the heart in 4 (2%), and the pancreas, the heart and the lungs in 2 (1%). We have incomplete information for 10 kidneys (7%). Immediate graft function occurred in 125 grafts (78%) (Group I); 31 kidneys (19%) had delayed graft function (DGF), 4 (2%) had technical failure (TF) (thrombosis), and 1 (1%) was a primary nonfunction (PNF) (Group II). Comparison with historical controls suggests that multiorgan retrieval had no impact on the incidence of DGF. Multivariate analysis demonstrated that the determinant factor in immediate graft function was the length of preservation 20 ± 8 hours for Group I vs 26 ± 8 for Group II. Patients with DGF had normal creatinine values at 3 and 6 months, similar to those with immediate function. We conclude that the combined simultaneous procurement of the kidney and other organs does not affect the outcome of the kidney transplant. DGF is related to perservation time.

KW - Kidney function

KW - Kidney transplantation

KW - Organ procurement

UR - http://www.scopus.com/inward/record.url?scp=0026350612&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0026350612&partnerID=8YFLogxK

M3 - Article

VL - 5

SP - 381

EP - 385

JO - Clinical Transplantation

JF - Clinical Transplantation

SN - 0902-0063

IS - 5

ER -