Multimodality in vivo imaging systems

Twice the power or double the trouble?

Research output: Contribution to journalArticle

150 Citations (Scopus)

Abstract

Many different types of radiation have been exploited to provide images of the structure and function of tissues inside a living subject. Each imaging modality is characterized by differing resolutions on the spatial and temporal scales, and by a different sensitivity for measuring properties related to morphology or function. Combinations of imaging modalities that integrate the strengths of two modalities, and at the same time eliminate one or more weaknesses of an individual modality, thus offer the prospect of improved diagnostics, therapeutic monitoring, and preclinical research using imaging approaches. This review discusses the advantages and challenges in developing multimodality imaging systems for in vivo use, highlights some successful combinations that are now routinely used in the clinic and in research, and discusses recent advances in multimodality instrumentation that may offer new opportunities for imaging.

Original languageEnglish (US)
Pages (from-to)35-62
Number of pages28
JournalAnnual Review of Biomedical Engineering
Volume8
DOIs
StatePublished - 2006

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Imaging systems
Imaging techniques
Research
Radiation
Tissue
Monitoring
Therapeutics

Keywords

  • Dual-modality
  • Instrumentation
  • PET/CT
  • PET/MRI
  • SPECT/CT

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering

Cite this

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title = "Multimodality in vivo imaging systems: Twice the power or double the trouble?",
abstract = "Many different types of radiation have been exploited to provide images of the structure and function of tissues inside a living subject. Each imaging modality is characterized by differing resolutions on the spatial and temporal scales, and by a different sensitivity for measuring properties related to morphology or function. Combinations of imaging modalities that integrate the strengths of two modalities, and at the same time eliminate one or more weaknesses of an individual modality, thus offer the prospect of improved diagnostics, therapeutic monitoring, and preclinical research using imaging approaches. This review discusses the advantages and challenges in developing multimodality imaging systems for in vivo use, highlights some successful combinations that are now routinely used in the clinic and in research, and discusses recent advances in multimodality instrumentation that may offer new opportunities for imaging.",
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