Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu; Ryan Nagao; Angelique Y. Louie

doi:10.1002/anie.200900984

Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu, Ryan Nagao, Angelique Y. Louie

Biomedical Engineering

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r₁ relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.

Original language	English (US)
Pages (from-to)	6547-6551
Number of pages	5
Journal	Angewandte Chemie - International Edition
Volume	48
Issue number	35
DOIs	https://doi.org/10.1002/anie.200900984
State	Published - 2009

Keywords

Biosensors
Gadolinium
Imaging
Imaging agents
Magnetic resonance
NADH

ASJC Scopus subject areas

Chemistry(all)
Catalysis
Medicine(all)

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abstract = "Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.",

keywords = "Biosensors, Gadolinium, Imaging, Imaging agents, Magnetic resonance, NADH",

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AU - Nagao, Ryan

AU - Louie, Angelique Y.

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AB - Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.

KW - Biosensors

KW - Gadolinium

KW - Imaging

KW - Imaging agents

KW - Magnetic resonance

KW - NADH

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ER -

Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Abstract

Keywords

ASJC Scopus subject areas

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