Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu, Ryan Nagao, Angelique Y. Louie

Research output: Contribution to journalArticle

70 Scopus citations

Abstract

Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.

Original languageEnglish (US)
Pages (from-to)6547-6551
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number35
DOIs
StatePublished - 2009

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Keywords

  • Biosensors
  • Gadolinium
  • Imaging
  • Imaging agents
  • Magnetic resonance
  • NADH

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

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