Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu, Ryan Nagao, Angelique Y. Louie

Research output: Contribution to journalArticlepeer-review

83 Scopus citations


Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.

Original languageEnglish (US)
Pages (from-to)6547-6551
Number of pages5
JournalAngewandte Chemie - International Edition
Issue number35
StatePublished - 2009


  • Biosensors
  • Gadolinium
  • Imaging
  • Imaging agents
  • Magnetic resonance
  • NADH

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)


Dive into the research topics of 'Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH'. Together they form a unique fingerprint.

Cite this