Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu, Ryan Nagao, Angelique Y. Louie

Research output: Contribution to journal › Article

70 Citations (Scopus)

Abstract

Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.

Original languageEnglish (US)
Pages (from-to)6547-6551
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number35
DOIs
StatePublished - 2009

Fingerprint

Optical Imaging
Gadolinium
Magnetic resonance
NAD
Contrast Media
Oxidation-Reduction
Fluorescence
Magnetic Resonance Imaging
Imaging techniques
Isomerization
Tissue

Keywords

  • Biosensors
  • Gadolinium
  • Imaging
  • Imaging agents
  • Magnetic resonance
  • NADH

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH. / Tu, Chuqiao; Nagao, Ryan; Louie, Angelique Y.

In: Angewandte Chemie - International Edition, Vol. 48, No. 35, 2009, p. 6547-6551.

Research output: Contribution to journal › Article

Tu, C, Nagao, R & Louie, AY 2009, 'Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH', Angewandte Chemie - International Edition, vol. 48, no. 35, pp. 6547-6551. https://doi.org/10.1002/anie.200900984
Tu C, Nagao R, Louie AY. Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH. Angewandte Chemie - International Edition. 2009;48(35):6547-6551. https://doi.org/10.1002/anie.200900984
Tu, Chuqiao ; Nagao, Ryan ; Louie, Angelique Y. / Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 35. pp. 6547-6551.
@article{d4303a4710c8452a8bc627ba6fc11979,
title = "Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH",
abstract = "Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 {\%}, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.",
keywords = "Biosensors, Gadolinium, Imaging, Imaging agents, Magnetic resonance, NADH",
author = "Chuqiao Tu and Ryan Nagao and Louie, {Angelique Y.}",
year = "2009",
doi = "10.1002/anie.200900984",
language = "English (US)",
volume = "48",
pages = "6547--6551",
journal = "Angewandte Chemie - International Edition",
issn = "1433-7851",
publisher = "John Wiley and Sons Ltd",
number = "35",

}

TY - JOUR

T1 - Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

AU - Tu, Chuqiao

AU - Nagao, Ryan

AU - Louie, Angelique Y.

PY - 2009

Y1 - 2009

N2 - Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.

AB - Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.

KW - Biosensors

KW - Gadolinium

KW - Imaging

KW - Imaging agents

KW - Magnetic resonance

KW - NADH

UR - http://www.scopus.com/inward/record.url?scp=70349907297&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=70349907297&partnerID=8YFLogxK

U2 - 10.1002/anie.200900984

DO - 10.1002/anie.200900984

M3 - Article

C2 - 19630041

AN - SCOPUS:70349907297

VL - 48

SP - 6547

EP - 6551

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 35

ER -

Access to Document