Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH

Chuqiao Tu, Ryan Nagao, Angelique Y. Louie

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Agents get smart: A macrocycle-based gadolinium complex undergoes an isomerization in the presence of NADH, leading to an r1 relaxivity increase of 54 %, while the intense fluorescence disappears (see scheme). This agent could facilitate the use of magnetic resonance imaging (MRI) for probing tissue redox status.

Original languageEnglish (US)
Pages (from-to)6547-6551
Number of pages5
JournalAngewandte Chemie - International Edition
Volume48
Issue number35
DOIs
StatePublished - 2009

Fingerprint

Optical Imaging
Gadolinium
Magnetic resonance
NAD
Contrast Media
Oxidation-Reduction
Fluorescence
Magnetic Resonance Imaging
Imaging techniques
Isomerization
Tissue

Keywords

  • Biosensors
  • Gadolinium
  • Imaging
  • Imaging agents
  • Magnetic resonance
  • NADH

ASJC Scopus subject areas

  • Chemistry(all)
  • Catalysis
  • Medicine(all)

Cite this

Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH. / Tu, Chuqiao; Nagao, Ryan; Louie, Angelique Y.

In: Angewandte Chemie - International Edition, Vol. 48, No. 35, 2009, p. 6547-6551.

Research output: Contribution to journalArticle

Tu, Chuqiao ; Nagao, Ryan ; Louie, Angelique Y. / Multimodal magnetic-resonance/optical-imaging contrast agent sensitive to NADH. In: Angewandte Chemie - International Edition. 2009 ; Vol. 48, No. 35. pp. 6547-6551.
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