Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques

Hussain Fatakdawala, Shannon Poti, Feifei Zhou, Yang Sun, Julien Bec, Jing Liu, Diego R. Yankelevich, Steven P. Tinling, Regina F Gandour-Edwards, D Gregory Farwell, Laura Marcu

Research output: Contribution to journalArticle

35 Scopus citations

Abstract

This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.

Original languageEnglish (US)
Pages (from-to)1724-1741
Number of pages18
JournalBiomedical Optics Express
Volume4
Issue number9
DOIs
StatePublished - 2013

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

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