Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques

Hussain Fatakdawala, Shannon Poti, Feifei Zhou, Yang Sun, Julien Bec, Jing Liu, Diego R. Yankelevich, Steven P. Tinling, Regina F Gandour-Edwards, D Gregory Farwell, Laura Marcu

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.

Original languageEnglish (US)
Pages (from-to)1724-1741
Number of pages18
JournalBiomedical Optics Express
Volume4
Issue number9
DOIs
StatePublished - 2013

Fingerprint

Photoacoustic Techniques
Mouth Neoplasms
Fluorescence
cancer
life (durability)
fluorescence
Optical Imaging
Carcinoma
Microscopy
microscopy
physiology
hamsters
Cricetinae
optical absorption

ASJC Scopus subject areas

  • Atomic and Molecular Physics, and Optics
  • Biotechnology

Cite this

Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques. / Fatakdawala, Hussain; Poti, Shannon; Zhou, Feifei; Sun, Yang; Bec, Julien; Liu, Jing; Yankelevich, Diego R.; Tinling, Steven P.; Gandour-Edwards, Regina F; Farwell, D Gregory; Marcu, Laura.

In: Biomedical Optics Express, Vol. 4, No. 9, 2013, p. 1724-1741.

Research output: Contribution to journalArticle

Fatakdawala, H, Poti, S, Zhou, F, Sun, Y, Bec, J, Liu, J, Yankelevich, DR, Tinling, SP, Gandour-Edwards, RF, Farwell, DG & Marcu, L 2013, 'Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques', Biomedical Optics Express, vol. 4, no. 9, pp. 1724-1741. https://doi.org/10.1364/BOE.4.001724
Fatakdawala, Hussain ; Poti, Shannon ; Zhou, Feifei ; Sun, Yang ; Bec, Julien ; Liu, Jing ; Yankelevich, Diego R. ; Tinling, Steven P. ; Gandour-Edwards, Regina F ; Farwell, D Gregory ; Marcu, Laura. / Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques. In: Biomedical Optics Express. 2013 ; Vol. 4, No. 9. pp. 1724-1741.
@article{a2762c19783c4815b8a30447f4bbaaf3,
title = "Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques",
abstract = "This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.",
author = "Hussain Fatakdawala and Shannon Poti and Feifei Zhou and Yang Sun and Julien Bec and Jing Liu and Yankelevich, {Diego R.} and Tinling, {Steven P.} and Gandour-Edwards, {Regina F} and Farwell, {D Gregory} and Laura Marcu",
year = "2013",
doi = "10.1364/BOE.4.001724",
language = "English (US)",
volume = "4",
pages = "1724--1741",
journal = "Biomedical Optics Express",
issn = "2156-7085",
publisher = "The Optical Society",
number = "9",

}

TY - JOUR

T1 - Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques

AU - Fatakdawala, Hussain

AU - Poti, Shannon

AU - Zhou, Feifei

AU - Sun, Yang

AU - Bec, Julien

AU - Liu, Jing

AU - Yankelevich, Diego R.

AU - Tinling, Steven P.

AU - Gandour-Edwards, Regina F

AU - Farwell, D Gregory

AU - Marcu, Laura

PY - 2013

Y1 - 2013

N2 - This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.

AB - This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.

UR - http://www.scopus.com/inward/record.url?scp=84883428000&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84883428000&partnerID=8YFLogxK

U2 - 10.1364/BOE.4.001724

DO - 10.1364/BOE.4.001724

M3 - Article

C2 - 24049693

AN - SCOPUS:84883428000

VL - 4

SP - 1724

EP - 1741

JO - Biomedical Optics Express

JF - Biomedical Optics Express

SN - 2156-7085

IS - 9

ER -