Abstract
This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1724-1741 |
| Number of pages | 18 |
| Journal | Biomedical Optics Express |
| Volume | 4 |
| Issue number | 9 |
| DOIs | |
| State | Published - 2013 |
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ASJC Scopus subject areas
- Atomic and Molecular Physics, and Optics
- Biotechnology
Cite this
Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques. / Fatakdawala, Hussain; Poti, Shannon; Zhou, Feifei; Sun, Yang; Bec, Julien; Liu, Jing; Yankelevich, Diego R.; Tinling, Steven P.; Gandour-Edwards, Regina F; Farwell, D Gregory; Marcu, Laura.
In: Biomedical Optics Express, Vol. 4, No. 9, 2013, p. 1724-1741.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multimodal in vivo imaging of oral cancer using fluorescence lifetime, photoacoustic and ultrasound techniques
AU - Fatakdawala, Hussain
AU - Poti, Shannon
AU - Zhou, Feifei
AU - Sun, Yang
AU - Bec, Julien
AU - Liu, Jing
AU - Yankelevich, Diego R.
AU - Tinling, Steven P.
AU - Gandour-Edwards, Regina F
AU - Farwell, D Gregory
AU - Marcu, Laura
PY - 2013
Y1 - 2013
N2 - This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.
AB - This work reports a multimodal system for label-free tissue diagnosis combining fluorescence lifetime imaging (FLIm), ultrasound backscatter microscopy (UBM), and photoacoustic imaging (PAI). This system provides complementary biochemical, structural and functional features allowing for enhanced in vivo detection of oral carcinoma. Results from a hamster oral carcinoma model (normal, precancer and carcinoma) are presented demonstrating the ability of FLIm to delineate biochemical composition at the tissue surface, UBM and related radiofrequency parameters to identify disruptions in the tissue microarchitecture and PAI to map optical absorption associated with specific tissue morphology and physiology.
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UR - http://www.scopus.com/inward/citedby.url?scp=84883428000&partnerID=8YFLogxK
U2 - 10.1364/BOE.4.001724
DO - 10.1364/BOE.4.001724
M3 - Article
C2 - 24049693
AN - SCOPUS:84883428000
VL - 4
SP - 1724
EP - 1741
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 9
ER -