Multimodal imaging of the self-regulating developing brain

Anders M. Fjell, Kristine Beate Walhovd, Timothy T. Brown, Joshua M. Kuperman, Yoonho Chung, Donald J. Hagler, Vijay Venkatraman, J. Cooper Roddey, Matthew Erhart, Connor McCabe, Natacha Akshoomoff, David G Amaral, Cinnamon S. Bloss, Ondrej Libiger, Burcu F. Darst, Nicholas J. Schork, B. J. Casey, Linda Chang, Thomas M. Ernst, Jeffrey R. GruenWalter E. Kaufmann, Tal Kenet, Jean Frazier, Sarah S. Murray, Elizabeth R. Sowell, Peter Van Zijl, Stewart Mostofsky, Terry L. Jernigan, Anders M. Dale

Research output: Contribution to journalArticle

135 Citations (Scopus)

Abstract

Self-regulation refers to the ability to control behavior, cognition, and emotions, and self-regulation failure is related to a range of neuropsychiatric problems. It is poorly understood how structural maturation of the brain brings about the gradual improvement in self-regulation during childhood. In a large-scale multicenter effort, 735 children (4-21 y) underwent structural MRI for quantification of cortical thickness and surface area and diffusion tensor imaging for quantification of the quality of major fiber connections. Brain development was related to a standardized measure of cognitive control (the flanker task from the National Institutes of Health Toolbox), a critical component of self-regulation. Ability to inhibit responses and impose cognitive control increased rapidly during preteen years. Surface area of the anterior cingulate cortex accounted for a significant proportion of the variance in cognitive performance. This finding is intriguing, because characteristics of the anterior cingulum are shown to be related to impulse, attention, and executive problems in neurodevelopmental disorders, indicating a neural foundation for self-regulation abilities along a continuumfrom normality to pathology. The relationship was strongest in the younger children. Properties of large-fiber connections added to the picture by explaining additional variance in cognitive control. Although cognitive control was related to surface area of the anterior cingulate independently of basic processes of mental speed, the relationship between white matter quality and cognitive control could be fully accounted for by speed. The results underscore the need for integration of different aspects of brain maturation to understand the foundations of cognitive development.

Original languageEnglish (US)
Pages (from-to)19620-19625
Number of pages6
JournalProceedings of the National Academy of Sciences of the United States of America
Volume109
Issue number48
DOIs
StatePublished - Nov 27 2012

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Multimodal Imaging
Aptitude
Brain
Gyrus Cinguli
Mental Processes
Behavior Control
Diffusion Tensor Imaging
National Institutes of Health (U.S.)
Quality Control
Cognition
Emotions
Self-Control
Pathology

Keywords

  • Cognitive conflict
  • Executive function
  • Inhibition
  • Morphometry

ASJC Scopus subject areas

  • General

Cite this

Fjell, A. M., Walhovd, K. B., Brown, T. T., Kuperman, J. M., Chung, Y., Hagler, D. J., ... Dale, A. M. (2012). Multimodal imaging of the self-regulating developing brain. Proceedings of the National Academy of Sciences of the United States of America, 109(48), 19620-19625. https://doi.org/10.1073/pnas.1208243109

Multimodal imaging of the self-regulating developing brain. / Fjell, Anders M.; Walhovd, Kristine Beate; Brown, Timothy T.; Kuperman, Joshua M.; Chung, Yoonho; Hagler, Donald J.; Venkatraman, Vijay; Cooper Roddey, J.; Erhart, Matthew; McCabe, Connor; Akshoomoff, Natacha; Amaral, David G; Bloss, Cinnamon S.; Libiger, Ondrej; Darst, Burcu F.; Schork, Nicholas J.; Casey, B. J.; Chang, Linda; Ernst, Thomas M.; Gruen, Jeffrey R.; Kaufmann, Walter E.; Kenet, Tal; Frazier, Jean; Murray, Sarah S.; Sowell, Elizabeth R.; Van Zijl, Peter; Mostofsky, Stewart; Jernigan, Terry L.; Dale, Anders M.

In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 109, No. 48, 27.11.2012, p. 19620-19625.

Research output: Contribution to journalArticle

Fjell, AM, Walhovd, KB, Brown, TT, Kuperman, JM, Chung, Y, Hagler, DJ, Venkatraman, V, Cooper Roddey, J, Erhart, M, McCabe, C, Akshoomoff, N, Amaral, DG, Bloss, CS, Libiger, O, Darst, BF, Schork, NJ, Casey, BJ, Chang, L, Ernst, TM, Gruen, JR, Kaufmann, WE, Kenet, T, Frazier, J, Murray, SS, Sowell, ER, Van Zijl, P, Mostofsky, S, Jernigan, TL & Dale, AM 2012, 'Multimodal imaging of the self-regulating developing brain', Proceedings of the National Academy of Sciences of the United States of America, vol. 109, no. 48, pp. 19620-19625. https://doi.org/10.1073/pnas.1208243109
Fjell, Anders M. ; Walhovd, Kristine Beate ; Brown, Timothy T. ; Kuperman, Joshua M. ; Chung, Yoonho ; Hagler, Donald J. ; Venkatraman, Vijay ; Cooper Roddey, J. ; Erhart, Matthew ; McCabe, Connor ; Akshoomoff, Natacha ; Amaral, David G ; Bloss, Cinnamon S. ; Libiger, Ondrej ; Darst, Burcu F. ; Schork, Nicholas J. ; Casey, B. J. ; Chang, Linda ; Ernst, Thomas M. ; Gruen, Jeffrey R. ; Kaufmann, Walter E. ; Kenet, Tal ; Frazier, Jean ; Murray, Sarah S. ; Sowell, Elizabeth R. ; Van Zijl, Peter ; Mostofsky, Stewart ; Jernigan, Terry L. ; Dale, Anders M. / Multimodal imaging of the self-regulating developing brain. In: Proceedings of the National Academy of Sciences of the United States of America. 2012 ; Vol. 109, No. 48. pp. 19620-19625.
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