TY - JOUR
T1 - Multimodal characterization of compositional, structural and functional features of human atherosclerotic plaques
AU - Sun, Yang
AU - Chaudhari, Abhijit
AU - Lam, Matthew
AU - Xie, Hongtao
AU - Yankelevich, Diego R.
AU - Phipps, Jennifer
AU - Liu, Jing
AU - Fishbein, Michael C.
AU - Cannata, Jonathan M.
AU - Shung, K. Kirk
AU - Marcu, Laura
PY - 2011/8/1
Y1 - 2011/8/1
N2 - Detection of atherosclerotic plaque vulnerability has critical clinical implications for avoiding sudden death in patients with high risk of plaque rupture. We report on multimodality imaging of ex-vivo human carotid plaque samples using a system that integrates fluorescence lifetime imaging (FLIM), ultrasonic backscatter microscopy (UBM), and photoacoustic imaging (PAI). Biochemical composition is differentiated with a high temporal resolution and sensitivity at the surface of the plaque by the FLIM subsystem. 3D microanatomy of the whole plaque is reconstructed by the UBM. Functional imaging associated with optical absorption contrast is evaluated from the PAI component. Simultaneous recordings of the optical, ultrasonic, and photoacoustic data present a wealth of complementary information concerning the plaque composition, structure, and function that are related to plaque vulnerability. This approach is expected to improve our ability to study atherosclerotic plaques. The multimodal system presented here can be translated into a catheter based intraluminal system for future clinical studies.
AB - Detection of atherosclerotic plaque vulnerability has critical clinical implications for avoiding sudden death in patients with high risk of plaque rupture. We report on multimodality imaging of ex-vivo human carotid plaque samples using a system that integrates fluorescence lifetime imaging (FLIM), ultrasonic backscatter microscopy (UBM), and photoacoustic imaging (PAI). Biochemical composition is differentiated with a high temporal resolution and sensitivity at the surface of the plaque by the FLIM subsystem. 3D microanatomy of the whole plaque is reconstructed by the UBM. Functional imaging associated with optical absorption contrast is evaluated from the PAI component. Simultaneous recordings of the optical, ultrasonic, and photoacoustic data present a wealth of complementary information concerning the plaque composition, structure, and function that are related to plaque vulnerability. This approach is expected to improve our ability to study atherosclerotic plaques. The multimodal system presented here can be translated into a catheter based intraluminal system for future clinical studies.
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M3 - Article
AN - SCOPUS:80455139026
VL - 2
SP - 2288
EP - 2298
JO - Biomedical Optics Express
JF - Biomedical Optics Express
SN - 2156-7085
IS - 8
ER -