Multilocus analysis of the fragile X syndrome

W. T. Brown, A. Gross, C. Chan, E. C. Jenkins, J. L. Mandel, I. Oberlé, B. Arveiler, G. Novelli, S. Thibodeau, Randi J Hagerman, K. Summers, G. Turner, B. N. White, L. Mulligan, C. Forster-Gibson, J. J A Holden, B. Zoll, M. Krawczak, P. Goonewardena, K. H. GustavsonU. Pettersson, G. Holmgren, C. Schwartz, P. N. Howard-Peebles, P. Murphy, W. R. Breg, H. Veenema, N. J. Carpenter

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Abstract

A multilocus analysis of the fragile X (fra(X)) syndrome was conducted with 147 families. Two proximal loci, DXS51 and F9, and two distal loci, DXS52 and DXS15, were studied. Overall, the best multipoint distances were found to be DXS51-F9, 6.9%, F9-fra(X), 22.4%; fra(X)-DXS52, 12.7%; DXS52-DXS15, 2.2%. These distances can be used for multipoint mapping of new probes, carrier testing and counseling of fra(X) families. Consistent with several previous studies, the families as a whole showed genetic heterogeneity for linkage between F9 and fra(X).

Original languageEnglish (US)
Pages (from-to)201-205
Number of pages5
JournalHuman Genetics
Volume78
Issue number3
DOIs
StatePublished - Mar 1988
Externally publishedYes

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Genetics

Cite this

Brown, W. T., Gross, A., Chan, C., Jenkins, E. C., Mandel, J. L., Oberlé, I., Arveiler, B., Novelli, G., Thibodeau, S., Hagerman, R. J., Summers, K., Turner, G., White, B. N., Mulligan, L., Forster-Gibson, C., Holden, J. J. A., Zoll, B., Krawczak, M., Goonewardena, P., ... Carpenter, N. J. (1988). Multilocus analysis of the fragile X syndrome. Human Genetics, 78(3), 201-205. https://doi.org/10.1007/BF00291662