TY - JOUR
T1 - Multilayer self-assembly of amphiphilic cyclodextrin hosts on bare and modified gold substrates
T2 - Controlling aggregation via surface modification
AU - Godínez, Luis A.
AU - Lin, James
AU - Muñoz, Marc
AU - Coleman, Anthony W.
AU - Rubin, Shai
AU - Parikh, Atul
AU - Zawodzinski, Thomas A.
AU - Loveday, David
AU - Ferraris, John P.
AU - Kaifer, Angel E.
PY - 1998/1/6
Y1 - 1998/1/6
N2 - Self-assembled multilayers of the three modified cyclodextrins (hexakis(2,3-O-hexyl-6-deoxy-6-amino)-a-cyclodextrin (1), heptakis(2,3-O-hexyl-6-deoxy-6-amino)-y3-cyclodextrin (2), and octakis(2,3-O-hexyl-6-deoxy-6-amino)-y-cyclodextrin (3)) on bare gold, as well as on gold surfaces modified with mercaptopropionic (4) and mercaptooctanoic (5) acid, were investigated by cyclic voltammetric, contact angle, FT-IR, and quartz crystal microbalance measurements in neutral aqueous media. The level of organization of the aggregates formed by the three CD derivatives (1-3) on the negatively charged surface of the mercaptopropionic and mercaptooctanoic acid modified gold electrodes proved to be substantially better than that on bare gold electrodes. This finding suggests that although the amphiphilic character of compounds 1-3 can induce aggregation on a gold surface, the electrostatic interaction between the carboxylic acid groups and the positively charged cyclodextrins is the primary force leading to the formation of well-organized aggregates.
AB - Self-assembled multilayers of the three modified cyclodextrins (hexakis(2,3-O-hexyl-6-deoxy-6-amino)-a-cyclodextrin (1), heptakis(2,3-O-hexyl-6-deoxy-6-amino)-y3-cyclodextrin (2), and octakis(2,3-O-hexyl-6-deoxy-6-amino)-y-cyclodextrin (3)) on bare gold, as well as on gold surfaces modified with mercaptopropionic (4) and mercaptooctanoic (5) acid, were investigated by cyclic voltammetric, contact angle, FT-IR, and quartz crystal microbalance measurements in neutral aqueous media. The level of organization of the aggregates formed by the three CD derivatives (1-3) on the negatively charged surface of the mercaptopropionic and mercaptooctanoic acid modified gold electrodes proved to be substantially better than that on bare gold electrodes. This finding suggests that although the amphiphilic character of compounds 1-3 can induce aggregation on a gold surface, the electrostatic interaction between the carboxylic acid groups and the positively charged cyclodextrins is the primary force leading to the formation of well-organized aggregates.
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M3 - Article
AN - SCOPUS:0032488492
VL - 14
SP - 137
EP - 144
JO - Langmuir
JF - Langmuir
SN - 0743-7463
IS - 1
ER -