Multifocal discrete osteolysis in a horse with silicate associated osteoporosis

R. Zavodovskaya, M. Eckert, B. G. Murphy, S. M. Stover, A. Kol, S. Diab

Research output: Contribution to journalArticle

Abstract

Silicate associated osteoporosis (SAO) was diagnosed post-mortem in an adult horse with the shortest documented exposure to cytotoxic silicates of 2 years. The horse was evaluated for a 6-month history of progressive back tenderness and acute onset of lameness. The horse had a marked (4/5) (American Association of Equine Practitioners scale) left forelimb lameness, moderate (2/5) hindlimb ataxia and weakness, and cervical pain upon palpation. Physical examination did not reveal clinical skeletal deformities or respiratory compromise. Radiographs revealed widespread, discrete, sharply delineated, osteolytic lesions in the skull, vertebral column, ribs, scapulae and middle phalanx (P2) of the left forelimb and a diffuse bronchointerstitial lung pattern. The presumptive clinical diagnosis was widespread, metastatic osteolytic neoplasia. Due to the poor quality of life and grave prognosis, the horse was humanely euthanised. Post-mortem examination revealed pulmonary silicosis in the lungs and hilar lymph nodes and osteolytic lesions with numerous, large osteoclasts and disorganised bone remodelling both consistent with SAO. SAO should be included as a differential diagnosis for horses with widespread, multifocal, discrete osteolysis and history of exposure to endemic regions with possible cytotoxic silicate inhalation. Exposure time of 2 years is potentially sufficient to develop SAO.

Original languageEnglish (US)
JournalEquine Veterinary Education
DOIs
StateAccepted/In press - Jan 1 2018

Fingerprint

Silicates
Osteolysis
osteoporosis
silicates
Horses
Osteoporosis
horses
Forelimb
lungs
forelimbs
lameness
lesions (animal)
Lung
scapula
Scapula
Silicosis
osteoclasts
Neck Pain
phalanges
Bone Remodeling

Keywords

  • Horse
  • Osteoclasts
  • Osteolysis
  • Osteoporosis
  • Silicosis

ASJC Scopus subject areas

  • Equine

Cite this

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abstract = "Silicate associated osteoporosis (SAO) was diagnosed post-mortem in an adult horse with the shortest documented exposure to cytotoxic silicates of 2 years. The horse was evaluated for a 6-month history of progressive back tenderness and acute onset of lameness. The horse had a marked (4/5) (American Association of Equine Practitioners scale) left forelimb lameness, moderate (2/5) hindlimb ataxia and weakness, and cervical pain upon palpation. Physical examination did not reveal clinical skeletal deformities or respiratory compromise. Radiographs revealed widespread, discrete, sharply delineated, osteolytic lesions in the skull, vertebral column, ribs, scapulae and middle phalanx (P2) of the left forelimb and a diffuse bronchointerstitial lung pattern. The presumptive clinical diagnosis was widespread, metastatic osteolytic neoplasia. Due to the poor quality of life and grave prognosis, the horse was humanely euthanised. Post-mortem examination revealed pulmonary silicosis in the lungs and hilar lymph nodes and osteolytic lesions with numerous, large osteoclasts and disorganised bone remodelling both consistent with SAO. SAO should be included as a differential diagnosis for horses with widespread, multifocal, discrete osteolysis and history of exposure to endemic regions with possible cytotoxic silicate inhalation. Exposure time of 2 years is potentially sufficient to develop SAO.",
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AU - Eckert, M.

AU - Murphy, B. G.

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AU - Kol, A.

AU - Diab, S.

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N2 - Silicate associated osteoporosis (SAO) was diagnosed post-mortem in an adult horse with the shortest documented exposure to cytotoxic silicates of 2 years. The horse was evaluated for a 6-month history of progressive back tenderness and acute onset of lameness. The horse had a marked (4/5) (American Association of Equine Practitioners scale) left forelimb lameness, moderate (2/5) hindlimb ataxia and weakness, and cervical pain upon palpation. Physical examination did not reveal clinical skeletal deformities or respiratory compromise. Radiographs revealed widespread, discrete, sharply delineated, osteolytic lesions in the skull, vertebral column, ribs, scapulae and middle phalanx (P2) of the left forelimb and a diffuse bronchointerstitial lung pattern. The presumptive clinical diagnosis was widespread, metastatic osteolytic neoplasia. Due to the poor quality of life and grave prognosis, the horse was humanely euthanised. Post-mortem examination revealed pulmonary silicosis in the lungs and hilar lymph nodes and osteolytic lesions with numerous, large osteoclasts and disorganised bone remodelling both consistent with SAO. SAO should be included as a differential diagnosis for horses with widespread, multifocal, discrete osteolysis and history of exposure to endemic regions with possible cytotoxic silicate inhalation. Exposure time of 2 years is potentially sufficient to develop SAO.

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