Multifocal bilateral choroidal neovascularization in a patient on ipilimumab for metastatic melanoma

Bobeck S. Modjtahedi, Howard Maibach, Susanna Soon Chun Park

Research output: Contribution to journalArticle

20 Scopus citations


Choroidal neovascularization membrane (CNVM) is a significant cause of ocular morbidity. Immunologic mechanisms have been proposed in the development of these lesions in exudative age related macular degeneration. Here, we describe the case of an 81-year-old man receiving ipilimumab, an immune modulating drug that enhances T cell response, for metastatic melanoma who developed three simultaneous CNVM bilaterally. This is the first case of ipilimumab-associated CNVM as well as the first case of an immune modulating drug possibly causing CNVM to our knowledge.

Original languageEnglish (US)
Pages (from-to)341-343
Number of pages3
JournalCutaneous and Ocular Toxicology
Issue number4
StatePublished - Oct 2013



  • Age related macular degeneration
  • Choroidal neovascularization
  • Drug reaction
  • Immunology
  • Ipilimumab
  • Melanoma
  • T cell

ASJC Scopus subject areas

  • Toxicology

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