Multifocal bilateral choroidal neovascularization in a patient on ipilimumab for metastatic melanoma

Bobeck S. Modjtahedi; Howard Maibach; Susanna Soon Chun Park

doi:10.3109/15569527.2013.781618

Multifocal bilateral choroidal neovascularization in a patient on ipilimumab for metastatic melanoma

Bobeck S. Modjtahedi, Howard Maibach, Susanna Soon Chun Park

Ophthalmology and Vision Science

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Choroidal neovascularization membrane (CNVM) is a significant cause of ocular morbidity. Immunologic mechanisms have been proposed in the development of these lesions in exudative age related macular degeneration. Here, we describe the case of an 81-year-old man receiving ipilimumab, an immune modulating drug that enhances T cell response, for metastatic melanoma who developed three simultaneous CNVM bilaterally. This is the first case of ipilimumab-associated CNVM as well as the first case of an immune modulating drug possibly causing CNVM to our knowledge.

Original language	English (US)
Pages (from-to)	341-343
Number of pages	3
Journal	Cutaneous and Ocular Toxicology
Volume	32
Issue number	4
DOIs	https://doi.org/10.3109/15569527.2013.781618
State	Published - Oct 2013

Keywords

Age related macular degeneration
Choroidal neovascularization
Drug reaction
Immunology
Ipilimumab
Melanoma
T cell

ASJC Scopus subject areas

Toxicology

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title = "Multifocal bilateral choroidal neovascularization in a patient on ipilimumab for metastatic melanoma",

abstract = "Choroidal neovascularization membrane (CNVM) is a significant cause of ocular morbidity. Immunologic mechanisms have been proposed in the development of these lesions in exudative age related macular degeneration. Here, we describe the case of an 81-year-old man receiving ipilimumab, an immune modulating drug that enhances T cell response, for metastatic melanoma who developed three simultaneous CNVM bilaterally. This is the first case of ipilimumab-associated CNVM as well as the first case of an immune modulating drug possibly causing CNVM to our knowledge.",

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