Multicomponent macrocyclization reactions (MCMRs) employing highly reactive acyl ketene and nitrile oxide intermediates

John M. Knapp, James C. Fettinger, Mark J. Kurth

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

An efficient synthesis of spiro-fused macrolactams by a multicomponent macrocyclization reaction (MCMR) is reported. The use of highly reactive, transient intermediates in this MCMR permits short reaction times, even at high dilution. The methods employed for this MCMR were first developed as a four-component strategy for the synthesis of β-ketoamide isoxazolines and a new macrocyclization reaction is reported.

Original languageEnglish (US)
Pages (from-to)4732-4735
Number of pages4
JournalOrganic Letters
Volume13
Issue number17
DOIs
StatePublished - Sep 2 2011

ASJC Scopus subject areas

  • Organic Chemistry
  • Physical and Theoretical Chemistry
  • Biochemistry

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