Multicompartmental analysis of the kinetics of radioiodinated monoclonal antibody in patients with cancer

K. Koizumi, Gerald L Denardo, S. J. DeNardo, M. T. Hays, H. H. Hines, P. O. Scheibe, J. S. Peng, D. J. Macey, N. Tonami, K. Hisada

Research output: Contribution to journalArticle

37 Citations (Scopus)

Abstract

A conceptual biologic model was developed and used to analyze the behavior of 123I-Lym-1-monoclonal antibody against African human B cell lymphoma in patients with B cell lymphoma. Originally, the observed data could not be stimulated with parameters for homologous immunoglobulins reported in the literature because of a major processor that was capable of distinguishing this murine immunoglobulin from the patient's own immunoglobulins. With a nonlinear parametric model, the data observed in patients could be fitted to the model. The nonlinear parameter determined the transfer of antibody from the intravascular to a processor compartment, primarily the liver. This transfer was a function of the number of free receptors in the processor. Model simulated curves for the time course of concentration of antibody in the blood for different amounts of injected antibody revealed that blood clearance of radiolabeled antibody was profoundly decreased by increased amount of injected antibody. This model provides an explanation for the observations that tumor imaging is improved with injection of larger amounts of antibody, and a basis for modifying the pharmacokinetic behavior of an antibody in order to optimize radioimmunodiagnosis and radioimmunotherapy.

Original languageEnglish (US)
Pages (from-to)1243-1254
Number of pages12
JournalJournal of Nuclear Medicine
Volume27
Issue number8
StatePublished - 1986
Externally publishedYes

Fingerprint

Monoclonal Antibodies
Antibodies
Neoplasms
Immunoglobulins
B-Cell Lymphoma
Radioimmunotherapy
Biological Models
Nonlinear Dynamics
Pharmacokinetics
Injections
Liver

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Cite this

Koizumi, K., Denardo, G. L., DeNardo, S. J., Hays, M. T., Hines, H. H., Scheibe, P. O., ... Hisada, K. (1986). Multicompartmental analysis of the kinetics of radioiodinated monoclonal antibody in patients with cancer. Journal of Nuclear Medicine, 27(8), 1243-1254.

Multicompartmental analysis of the kinetics of radioiodinated monoclonal antibody in patients with cancer. / Koizumi, K.; Denardo, Gerald L; DeNardo, S. J.; Hays, M. T.; Hines, H. H.; Scheibe, P. O.; Peng, J. S.; Macey, D. J.; Tonami, N.; Hisada, K.

In: Journal of Nuclear Medicine, Vol. 27, No. 8, 1986, p. 1243-1254.

Research output: Contribution to journalArticle

Koizumi, K, Denardo, GL, DeNardo, SJ, Hays, MT, Hines, HH, Scheibe, PO, Peng, JS, Macey, DJ, Tonami, N & Hisada, K 1986, 'Multicompartmental analysis of the kinetics of radioiodinated monoclonal antibody in patients with cancer', Journal of Nuclear Medicine, vol. 27, no. 8, pp. 1243-1254.
Koizumi, K. ; Denardo, Gerald L ; DeNardo, S. J. ; Hays, M. T. ; Hines, H. H. ; Scheibe, P. O. ; Peng, J. S. ; Macey, D. J. ; Tonami, N. ; Hisada, K. / Multicompartmental analysis of the kinetics of radioiodinated monoclonal antibody in patients with cancer. In: Journal of Nuclear Medicine. 1986 ; Vol. 27, No. 8. pp. 1243-1254.
@article{0d3c749c544040d1b3970a611ddf8f73,
title = "Multicompartmental analysis of the kinetics of radioiodinated monoclonal antibody in patients with cancer",
abstract = "A conceptual biologic model was developed and used to analyze the behavior of 123I-Lym-1-monoclonal antibody against African human B cell lymphoma in patients with B cell lymphoma. Originally, the observed data could not be stimulated with parameters for homologous immunoglobulins reported in the literature because of a major processor that was capable of distinguishing this murine immunoglobulin from the patient's own immunoglobulins. With a nonlinear parametric model, the data observed in patients could be fitted to the model. The nonlinear parameter determined the transfer of antibody from the intravascular to a processor compartment, primarily the liver. This transfer was a function of the number of free receptors in the processor. Model simulated curves for the time course of concentration of antibody in the blood for different amounts of injected antibody revealed that blood clearance of radiolabeled antibody was profoundly decreased by increased amount of injected antibody. This model provides an explanation for the observations that tumor imaging is improved with injection of larger amounts of antibody, and a basis for modifying the pharmacokinetic behavior of an antibody in order to optimize radioimmunodiagnosis and radioimmunotherapy.",
author = "K. Koizumi and Denardo, {Gerald L} and DeNardo, {S. J.} and Hays, {M. T.} and Hines, {H. H.} and Scheibe, {P. O.} and Peng, {J. S.} and Macey, {D. J.} and N. Tonami and K. Hisada",
year = "1986",
language = "English (US)",
volume = "27",
pages = "1243--1254",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "8",

}

TY - JOUR

T1 - Multicompartmental analysis of the kinetics of radioiodinated monoclonal antibody in patients with cancer

AU - Koizumi, K.

AU - Denardo, Gerald L

AU - DeNardo, S. J.

AU - Hays, M. T.

AU - Hines, H. H.

AU - Scheibe, P. O.

AU - Peng, J. S.

AU - Macey, D. J.

AU - Tonami, N.

AU - Hisada, K.

PY - 1986

Y1 - 1986

N2 - A conceptual biologic model was developed and used to analyze the behavior of 123I-Lym-1-monoclonal antibody against African human B cell lymphoma in patients with B cell lymphoma. Originally, the observed data could not be stimulated with parameters for homologous immunoglobulins reported in the literature because of a major processor that was capable of distinguishing this murine immunoglobulin from the patient's own immunoglobulins. With a nonlinear parametric model, the data observed in patients could be fitted to the model. The nonlinear parameter determined the transfer of antibody from the intravascular to a processor compartment, primarily the liver. This transfer was a function of the number of free receptors in the processor. Model simulated curves for the time course of concentration of antibody in the blood for different amounts of injected antibody revealed that blood clearance of radiolabeled antibody was profoundly decreased by increased amount of injected antibody. This model provides an explanation for the observations that tumor imaging is improved with injection of larger amounts of antibody, and a basis for modifying the pharmacokinetic behavior of an antibody in order to optimize radioimmunodiagnosis and radioimmunotherapy.

AB - A conceptual biologic model was developed and used to analyze the behavior of 123I-Lym-1-monoclonal antibody against African human B cell lymphoma in patients with B cell lymphoma. Originally, the observed data could not be stimulated with parameters for homologous immunoglobulins reported in the literature because of a major processor that was capable of distinguishing this murine immunoglobulin from the patient's own immunoglobulins. With a nonlinear parametric model, the data observed in patients could be fitted to the model. The nonlinear parameter determined the transfer of antibody from the intravascular to a processor compartment, primarily the liver. This transfer was a function of the number of free receptors in the processor. Model simulated curves for the time course of concentration of antibody in the blood for different amounts of injected antibody revealed that blood clearance of radiolabeled antibody was profoundly decreased by increased amount of injected antibody. This model provides an explanation for the observations that tumor imaging is improved with injection of larger amounts of antibody, and a basis for modifying the pharmacokinetic behavior of an antibody in order to optimize radioimmunodiagnosis and radioimmunotherapy.

UR - http://www.scopus.com/inward/record.url?scp=0022881227&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0022881227&partnerID=8YFLogxK

M3 - Article

C2 - 3488377

AN - SCOPUS:0022881227

VL - 27

SP - 1243

EP - 1254

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 8

ER -