Multicentric T-cell lymphoma associated with feline leukemia virus infection in a captive Namibian cheetah (Acinonyx jubatus)

Laurie Marker, Linda Munson, Peter A. Basson, Sandra Quackenbush

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

This case report describes a multicentric lymphoma in a 4 yr old female wildborn captive cheetah (Acinonyx jubatus) in Namibia after being housed in an enclosure adjacent to a feline leukemia virus (FeLV) infected cheetah that had previously been in contact with domestic cats. The year prior to the onset of clinical signs, the wild-born cheetah was FeLV antigen negative. The cheetah subsequently developed lymphoma, was found to be infected With FeLV, and then rapidly deteriorated and died. At necropsy, the liver, spleen, lymph nodes, and multiple other organs were extensively infiltrated with neoplastic T-lymphocytes. Feline leukemia virus DNA was identified in neoplastic lymphocytes from multiple organs by polymerase chain reaction and Southern blot analysis. Although the outcome of infection in this cheetah resembles that of FeLV infections in domestic cats, the transmission across an enclosure fence was unusual and may indicate a heightened susceptibility to infection in cheetahs. Caution should be exercised in holding and translocating cheetahs where contact could be made with FeLV-infected domestic, feral, or wild felids.

Original languageEnglish (US)
Pages (from-to)690-695
Number of pages6
JournalJournal of Wildlife Diseases
Volume39
Issue number3
StatePublished - Jul 2003

Fingerprint

Acinonyx
Feline Leukemia Virus
Acinonyx jubatus
Feline leukemia virus
T-Cell Lymphoma
Virus Diseases
lymphoma
virus
T-lymphocytes
infection
felid
Lymphoma
Cats
Namibia
cats
antigen
polymerase chain reaction
Felidae
leukaemia
fences

Keywords

  • Acinonyx jubatus
  • Case report
  • Cheetah
  • Feline leukemia virus
  • Lymphoma
  • Namibia
  • T-lymphocyte

ASJC Scopus subject areas

  • veterinary(all)

Cite this

Multicentric T-cell lymphoma associated with feline leukemia virus infection in a captive Namibian cheetah (Acinonyx jubatus). / Marker, Laurie; Munson, Linda; Basson, Peter A.; Quackenbush, Sandra.

In: Journal of Wildlife Diseases, Vol. 39, No. 3, 07.2003, p. 690-695.

Research output: Contribution to journalArticle

Marker, Laurie ; Munson, Linda ; Basson, Peter A. ; Quackenbush, Sandra. / Multicentric T-cell lymphoma associated with feline leukemia virus infection in a captive Namibian cheetah (Acinonyx jubatus). In: Journal of Wildlife Diseases. 2003 ; Vol. 39, No. 3. pp. 690-695.
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