Abstract
Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease that primarily manifests clinically with severe erosive arthritis and widespread papulonodular skin lesions but can involve multiple other organ systems. Despite the fact that this condition can become aggressive, debilitating as well as deforming with significant detrimental consequences, the etiology of this disease remains poorly understood. Moreover, the fact that MRH is such an uncommon disease has created an obstacle in the path of adequate clinical trials that are needed for better understanding of this phenomenon and for the development of treatment options for this patient population. In this review, we will attempt to discuss the epidemiology, pathophysiology, clinical features, associated conditions, differential diagnoses, diagnostic workup, and available treatments of MRH with the hope of creating a better understanding of this very challenging yet elusive disease process.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 281-289 |
| Number of pages | 9 |
| Journal | Clinical Reviews in Allergy and Immunology |
| Volume | 45 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 2013 |
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Keywords
- Ground glass eosinophilic cytoplasm
- Histiocytosis
- Multinucleated giant cells
- Papulonodular cutaneous lesions
- Symmetric erosive arthritis
ASJC Scopus subject areas
- Immunology and Allergy
Cite this
Multicentric reticulohistiocytosis : A rare yet challenging disease. / Islam, Arshia D.; Naguwa, Stanley M; Cheema, Gurtej S.; Hunter, John C; Gershwin, M. Eric.
In: Clinical Reviews in Allergy and Immunology, Vol. 45, No. 2, 10.2013, p. 281-289.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Multicentric reticulohistiocytosis
T2 - A rare yet challenging disease
AU - Islam, Arshia D.
AU - Naguwa, Stanley M
AU - Cheema, Gurtej S.
AU - Hunter, John C
AU - Gershwin, M. Eric
PY - 2013/10
Y1 - 2013/10
N2 - Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease that primarily manifests clinically with severe erosive arthritis and widespread papulonodular skin lesions but can involve multiple other organ systems. Despite the fact that this condition can become aggressive, debilitating as well as deforming with significant detrimental consequences, the etiology of this disease remains poorly understood. Moreover, the fact that MRH is such an uncommon disease has created an obstacle in the path of adequate clinical trials that are needed for better understanding of this phenomenon and for the development of treatment options for this patient population. In this review, we will attempt to discuss the epidemiology, pathophysiology, clinical features, associated conditions, differential diagnoses, diagnostic workup, and available treatments of MRH with the hope of creating a better understanding of this very challenging yet elusive disease process.
AB - Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease that primarily manifests clinically with severe erosive arthritis and widespread papulonodular skin lesions but can involve multiple other organ systems. Despite the fact that this condition can become aggressive, debilitating as well as deforming with significant detrimental consequences, the etiology of this disease remains poorly understood. Moreover, the fact that MRH is such an uncommon disease has created an obstacle in the path of adequate clinical trials that are needed for better understanding of this phenomenon and for the development of treatment options for this patient population. In this review, we will attempt to discuss the epidemiology, pathophysiology, clinical features, associated conditions, differential diagnoses, diagnostic workup, and available treatments of MRH with the hope of creating a better understanding of this very challenging yet elusive disease process.
KW - Ground glass eosinophilic cytoplasm
KW - Histiocytosis
KW - Multinucleated giant cells
KW - Papulonodular cutaneous lesions
KW - Symmetric erosive arthritis
UR - http://www.scopus.com/inward/record.url?scp=84884905720&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84884905720&partnerID=8YFLogxK
U2 - 10.1007/s12016-013-8362-2
DO - 10.1007/s12016-013-8362-2
M3 - Article
C2 - 23417597
AN - SCOPUS:84884905720
VL - 45
SP - 281
EP - 289
JO - Clinical Reviews in Allergy and Immunology
JF - Clinical Reviews in Allergy and Immunology
SN - 1080-0549
IS - 2
ER -