Multicentric reticulohistiocytosis: A rare yet challenging disease

Research output: Contribution to journalArticle

22 Citations (Scopus)

Abstract

Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease that primarily manifests clinically with severe erosive arthritis and widespread papulonodular skin lesions but can involve multiple other organ systems. Despite the fact that this condition can become aggressive, debilitating as well as deforming with significant detrimental consequences, the etiology of this disease remains poorly understood. Moreover, the fact that MRH is such an uncommon disease has created an obstacle in the path of adequate clinical trials that are needed for better understanding of this phenomenon and for the development of treatment options for this patient population. In this review, we will attempt to discuss the epidemiology, pathophysiology, clinical features, associated conditions, differential diagnoses, diagnostic workup, and available treatments of MRH with the hope of creating a better understanding of this very challenging yet elusive disease process.

Original languageEnglish (US)
Pages (from-to)281-289
Number of pages9
JournalClinical Reviews in Allergy and Immunology
Volume45
Issue number2
DOIs
StatePublished - Oct 2013

Fingerprint

Arthritis
Epidemiology
Differential Diagnosis
Clinical Trials
Skin
Therapeutics
Population

Keywords

  • Ground glass eosinophilic cytoplasm
  • Histiocytosis
  • Multinucleated giant cells
  • Papulonodular cutaneous lesions
  • Symmetric erosive arthritis

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

@article{437e0aac59bf4f1f85ea514e5f5fb7ae,
title = "Multicentric reticulohistiocytosis: A rare yet challenging disease",
abstract = "Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease that primarily manifests clinically with severe erosive arthritis and widespread papulonodular skin lesions but can involve multiple other organ systems. Despite the fact that this condition can become aggressive, debilitating as well as deforming with significant detrimental consequences, the etiology of this disease remains poorly understood. Moreover, the fact that MRH is such an uncommon disease has created an obstacle in the path of adequate clinical trials that are needed for better understanding of this phenomenon and for the development of treatment options for this patient population. In this review, we will attempt to discuss the epidemiology, pathophysiology, clinical features, associated conditions, differential diagnoses, diagnostic workup, and available treatments of MRH with the hope of creating a better understanding of this very challenging yet elusive disease process.",
keywords = "Ground glass eosinophilic cytoplasm, Histiocytosis, Multinucleated giant cells, Papulonodular cutaneous lesions, Symmetric erosive arthritis",
author = "Islam, {Arshia D.} and Naguwa, {Stanley M} and Cheema, {Gurtej S.} and Hunter, {John C} and Gershwin, {M. Eric}",
year = "2013",
month = "10",
doi = "10.1007/s12016-013-8362-2",
language = "English (US)",
volume = "45",
pages = "281--289",
journal = "Clinical Reviews in Allergy and Immunology",
issn = "1080-0549",
publisher = "Humana Press",
number = "2",

}

TY - JOUR

T1 - Multicentric reticulohistiocytosis

T2 - A rare yet challenging disease

AU - Islam, Arshia D.

AU - Naguwa, Stanley M

AU - Cheema, Gurtej S.

AU - Hunter, John C

AU - Gershwin, M. Eric

PY - 2013/10

Y1 - 2013/10

N2 - Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease that primarily manifests clinically with severe erosive arthritis and widespread papulonodular skin lesions but can involve multiple other organ systems. Despite the fact that this condition can become aggressive, debilitating as well as deforming with significant detrimental consequences, the etiology of this disease remains poorly understood. Moreover, the fact that MRH is such an uncommon disease has created an obstacle in the path of adequate clinical trials that are needed for better understanding of this phenomenon and for the development of treatment options for this patient population. In this review, we will attempt to discuss the epidemiology, pathophysiology, clinical features, associated conditions, differential diagnoses, diagnostic workup, and available treatments of MRH with the hope of creating a better understanding of this very challenging yet elusive disease process.

AB - Multicentric reticulohistiocytosis (MRH) is a rare systemic inflammatory granulomatous disease that primarily manifests clinically with severe erosive arthritis and widespread papulonodular skin lesions but can involve multiple other organ systems. Despite the fact that this condition can become aggressive, debilitating as well as deforming with significant detrimental consequences, the etiology of this disease remains poorly understood. Moreover, the fact that MRH is such an uncommon disease has created an obstacle in the path of adequate clinical trials that are needed for better understanding of this phenomenon and for the development of treatment options for this patient population. In this review, we will attempt to discuss the epidemiology, pathophysiology, clinical features, associated conditions, differential diagnoses, diagnostic workup, and available treatments of MRH with the hope of creating a better understanding of this very challenging yet elusive disease process.

KW - Ground glass eosinophilic cytoplasm

KW - Histiocytosis

KW - Multinucleated giant cells

KW - Papulonodular cutaneous lesions

KW - Symmetric erosive arthritis

UR - http://www.scopus.com/inward/record.url?scp=84884905720&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84884905720&partnerID=8YFLogxK

U2 - 10.1007/s12016-013-8362-2

DO - 10.1007/s12016-013-8362-2

M3 - Article

C2 - 23417597

AN - SCOPUS:84884905720

VL - 45

SP - 281

EP - 289

JO - Clinical Reviews in Allergy and Immunology

JF - Clinical Reviews in Allergy and Immunology

SN - 1080-0549

IS - 2

ER -