Multicentric primary extramammary paget disease: A Toker cell disorder?

Pantea Hashemi, Grace F. Kao, Thomas Konia, Lisa C. Kauffman, Christine C. Tam, Bahram Sina

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

Toker cells are epithelial clear cells found in the areolar and nipple areas of the breast, vulvar region, and other apocrine gland-bearing areas of the skin. Toker cells have been implicated in the pathogenesis of clear cell papulosis, cutaneous hamartoma with pagetoid cells, and rare cases of primary extramammary Paget disease (EMPD) but not in secondary EMPD with underlying adenocarcinoma. The pathogenesis of primary EMPD is not well defined. We report a case of multicentric primary EMPD with evidence of Toker cell proliferation and nonaggressive biologic behavior in a 63-year-old white man. A detailed description of the morphologic and biologic features of Toker cells and their possible carcinogenetic links also are discussed. Based on the observation and follow-up of our patient, we hypothesize that multicentric primary EMPD starts with Toker cell hyperplasia and can potentially evolve to carcinoma in the genital region.

Original languageEnglish (US)
Pages (from-to)35-38
Number of pages4
JournalCutis
Volume94
Issue number1
StatePublished - 2014

ASJC Scopus subject areas

  • Dermatology

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    Hashemi, P., Kao, G. F., Konia, T., Kauffman, L. C., Tam, C. C., & Sina, B. (2014). Multicentric primary extramammary paget disease: A Toker cell disorder? Cutis, 94(1), 35-38.