Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes

F. Xavier Pi-Sunyer, Carol A. Maggio, David A. McCarron, Molly E. Reusser, Judith S. Stern, R. Brian Haynes, Suzanne Oparil, Penny Kris-Etherton, Lawrence M. Resnick, Alan Chait, Cynthia D. Morris, Daniel C. Hatton, Jill A. Metz, Geoffrey W. Snyder, Sharon Clark, Margaret McMahon

Research output: Contribution to journalArticle

46 Citations (Scopus)

Abstract

OBJECTIVE - To evaluate the clinical effects of a comprehensive prepackaged meal plan, incorporating the overall dietary guidelines of the American Diabetes Association and other national health organizations, relative to those of a self-selected diet based on exchange lists in free- living individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS - A total of 202 women and men (BMI ≤42 kg/m2) whose diabetes was treated with diet alone or an oral hypoglycemic agent were enrolled at 10 medical centers. After a 4-week baseline period, participants were randomized to a nutrient- fortified prepared meal plan or a self-selected exchange-list diet for 10 weeks. On a caloric basis, both interventions were designed to provide 55- 60% carbohydrate, 20-30% fat, and 15-20% protein. At intervals, 3-day food records were completed, and body weight, glycemic control, plasma lipids, and blood pressure were assessed. RESULTS - Food records showed that multiple nutritional improvements were achieved with both diet plans. There were significant overall reductions in body weight and BMI, fasting plasma glucose and serum insulin, fructosamine, HbA(1c), total and LDL cholesterol, and blood pressure (P < 0.001 or better for all). In general, differences in major end points between the diet plans were not statistically significant. CONCLUSIONS - Glycemic control and cardiovascular risk factors improve in individuals with type 2 diabetes who consume diets in accordance with the American Diabetes Association guidelines. The prepared meal program was as clinically effective as the exchange-list diet. The prepared meal plan has the additional advantages of being easily prescribed and eliminating the complexities of meeting the multiple dietary recommendations for type 2 diabetes management.

Original languageEnglish (US)
Pages (from-to)191-197
Number of pages7
JournalDiabetes Care
Volume22
Issue number2
DOIs
StatePublished - Feb 1999

Fingerprint

Type 2 Diabetes Mellitus
Multicenter Studies
Meals
Diet
Food
Body Weight
Fructosamine
Blood Pressure
Nutrition Policy
Hypoglycemic Agents
LDL Cholesterol
Fasting
Research Design
Fats
Carbohydrates
Organizations
Guidelines
Insulin
Lipids
Glucose

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism

Cite this

Pi-Sunyer, F. X., Maggio, C. A., McCarron, D. A., Reusser, M. E., Stern, J. S., Haynes, R. B., ... McMahon, M. (1999). Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes. Diabetes Care, 22(2), 191-197. https://doi.org/10.2337/diacare.22.2.191

Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes. / Pi-Sunyer, F. Xavier; Maggio, Carol A.; McCarron, David A.; Reusser, Molly E.; Stern, Judith S.; Haynes, R. Brian; Oparil, Suzanne; Kris-Etherton, Penny; Resnick, Lawrence M.; Chait, Alan; Morris, Cynthia D.; Hatton, Daniel C.; Metz, Jill A.; Snyder, Geoffrey W.; Clark, Sharon; McMahon, Margaret.

In: Diabetes Care, Vol. 22, No. 2, 02.1999, p. 191-197.

Research output: Contribution to journalArticle

Pi-Sunyer, FX, Maggio, CA, McCarron, DA, Reusser, ME, Stern, JS, Haynes, RB, Oparil, S, Kris-Etherton, P, Resnick, LM, Chait, A, Morris, CD, Hatton, DC, Metz, JA, Snyder, GW, Clark, S & McMahon, M 1999, 'Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes', Diabetes Care, vol. 22, no. 2, pp. 191-197. https://doi.org/10.2337/diacare.22.2.191
Pi-Sunyer FX, Maggio CA, McCarron DA, Reusser ME, Stern JS, Haynes RB et al. Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes. Diabetes Care. 1999 Feb;22(2):191-197. https://doi.org/10.2337/diacare.22.2.191
Pi-Sunyer, F. Xavier ; Maggio, Carol A. ; McCarron, David A. ; Reusser, Molly E. ; Stern, Judith S. ; Haynes, R. Brian ; Oparil, Suzanne ; Kris-Etherton, Penny ; Resnick, Lawrence M. ; Chait, Alan ; Morris, Cynthia D. ; Hatton, Daniel C. ; Metz, Jill A. ; Snyder, Geoffrey W. ; Clark, Sharon ; McMahon, Margaret. / Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes. In: Diabetes Care. 1999 ; Vol. 22, No. 2. pp. 191-197.
@article{18ebb8d7638846c8893774851e0ed84b,
title = "Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes",
abstract = "OBJECTIVE - To evaluate the clinical effects of a comprehensive prepackaged meal plan, incorporating the overall dietary guidelines of the American Diabetes Association and other national health organizations, relative to those of a self-selected diet based on exchange lists in free- living individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS - A total of 202 women and men (BMI ≤42 kg/m2) whose diabetes was treated with diet alone or an oral hypoglycemic agent were enrolled at 10 medical centers. After a 4-week baseline period, participants were randomized to a nutrient- fortified prepared meal plan or a self-selected exchange-list diet for 10 weeks. On a caloric basis, both interventions were designed to provide 55- 60{\%} carbohydrate, 20-30{\%} fat, and 15-20{\%} protein. At intervals, 3-day food records were completed, and body weight, glycemic control, plasma lipids, and blood pressure were assessed. RESULTS - Food records showed that multiple nutritional improvements were achieved with both diet plans. There were significant overall reductions in body weight and BMI, fasting plasma glucose and serum insulin, fructosamine, HbA(1c), total and LDL cholesterol, and blood pressure (P < 0.001 or better for all). In general, differences in major end points between the diet plans were not statistically significant. CONCLUSIONS - Glycemic control and cardiovascular risk factors improve in individuals with type 2 diabetes who consume diets in accordance with the American Diabetes Association guidelines. The prepared meal program was as clinically effective as the exchange-list diet. The prepared meal plan has the additional advantages of being easily prescribed and eliminating the complexities of meeting the multiple dietary recommendations for type 2 diabetes management.",
author = "Pi-Sunyer, {F. Xavier} and Maggio, {Carol A.} and McCarron, {David A.} and Reusser, {Molly E.} and Stern, {Judith S.} and Haynes, {R. Brian} and Suzanne Oparil and Penny Kris-Etherton and Resnick, {Lawrence M.} and Alan Chait and Morris, {Cynthia D.} and Hatton, {Daniel C.} and Metz, {Jill A.} and Snyder, {Geoffrey W.} and Sharon Clark and Margaret McMahon",
year = "1999",
month = "2",
doi = "10.2337/diacare.22.2.191",
language = "English (US)",
volume = "22",
pages = "191--197",
journal = "Diabetes Care",
issn = "1935-5548",
publisher = "American Diabetes Association Inc.",
number = "2",

}

TY - JOUR

T1 - Multicenter randomized trial of a comprehensive prepared meal program in type 2 diabetes

AU - Pi-Sunyer, F. Xavier

AU - Maggio, Carol A.

AU - McCarron, David A.

AU - Reusser, Molly E.

AU - Stern, Judith S.

AU - Haynes, R. Brian

AU - Oparil, Suzanne

AU - Kris-Etherton, Penny

AU - Resnick, Lawrence M.

AU - Chait, Alan

AU - Morris, Cynthia D.

AU - Hatton, Daniel C.

AU - Metz, Jill A.

AU - Snyder, Geoffrey W.

AU - Clark, Sharon

AU - McMahon, Margaret

PY - 1999/2

Y1 - 1999/2

N2 - OBJECTIVE - To evaluate the clinical effects of a comprehensive prepackaged meal plan, incorporating the overall dietary guidelines of the American Diabetes Association and other national health organizations, relative to those of a self-selected diet based on exchange lists in free- living individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS - A total of 202 women and men (BMI ≤42 kg/m2) whose diabetes was treated with diet alone or an oral hypoglycemic agent were enrolled at 10 medical centers. After a 4-week baseline period, participants were randomized to a nutrient- fortified prepared meal plan or a self-selected exchange-list diet for 10 weeks. On a caloric basis, both interventions were designed to provide 55- 60% carbohydrate, 20-30% fat, and 15-20% protein. At intervals, 3-day food records were completed, and body weight, glycemic control, plasma lipids, and blood pressure were assessed. RESULTS - Food records showed that multiple nutritional improvements were achieved with both diet plans. There were significant overall reductions in body weight and BMI, fasting plasma glucose and serum insulin, fructosamine, HbA(1c), total and LDL cholesterol, and blood pressure (P < 0.001 or better for all). In general, differences in major end points between the diet plans were not statistically significant. CONCLUSIONS - Glycemic control and cardiovascular risk factors improve in individuals with type 2 diabetes who consume diets in accordance with the American Diabetes Association guidelines. The prepared meal program was as clinically effective as the exchange-list diet. The prepared meal plan has the additional advantages of being easily prescribed and eliminating the complexities of meeting the multiple dietary recommendations for type 2 diabetes management.

AB - OBJECTIVE - To evaluate the clinical effects of a comprehensive prepackaged meal plan, incorporating the overall dietary guidelines of the American Diabetes Association and other national health organizations, relative to those of a self-selected diet based on exchange lists in free- living individuals with type 2 diabetes. RESEARCH DESIGN AND METHODS - A total of 202 women and men (BMI ≤42 kg/m2) whose diabetes was treated with diet alone or an oral hypoglycemic agent were enrolled at 10 medical centers. After a 4-week baseline period, participants were randomized to a nutrient- fortified prepared meal plan or a self-selected exchange-list diet for 10 weeks. On a caloric basis, both interventions were designed to provide 55- 60% carbohydrate, 20-30% fat, and 15-20% protein. At intervals, 3-day food records were completed, and body weight, glycemic control, plasma lipids, and blood pressure were assessed. RESULTS - Food records showed that multiple nutritional improvements were achieved with both diet plans. There were significant overall reductions in body weight and BMI, fasting plasma glucose and serum insulin, fructosamine, HbA(1c), total and LDL cholesterol, and blood pressure (P < 0.001 or better for all). In general, differences in major end points between the diet plans were not statistically significant. CONCLUSIONS - Glycemic control and cardiovascular risk factors improve in individuals with type 2 diabetes who consume diets in accordance with the American Diabetes Association guidelines. The prepared meal program was as clinically effective as the exchange-list diet. The prepared meal plan has the additional advantages of being easily prescribed and eliminating the complexities of meeting the multiple dietary recommendations for type 2 diabetes management.

UR - http://www.scopus.com/inward/record.url?scp=0032934103&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0032934103&partnerID=8YFLogxK

U2 - 10.2337/diacare.22.2.191

DO - 10.2337/diacare.22.2.191

M3 - Article

C2 - 10333932

AN - SCOPUS:0032934103

VL - 22

SP - 191

EP - 197

JO - Diabetes Care

JF - Diabetes Care

SN - 1935-5548

IS - 2

ER -