Multicenter comparison of the contraceptive ring and patch: A randomized controlled trial

Mitchell D Creinin, Leslie A. Meyn, Lynn Borgatta, Kurt Barnhart, Jeff Jensen, Anne E. Burke, Carolyn Westhoff, Melissa Gilliam, Caryn Dutton, Susan A. Ballagh

Research output: Contribution to journalArticle

66 Scopus citations

Abstract

OBJECTIVE: To understand if the contraceptive ring or patch was more acceptable, as measured primarily by continuation, to women using an oral contraceptive and interested in a nondaily, combined hormonal contraceptive. METHODS: Five hundred women were randomly assigned to use the contraceptive ring (n=249) or contraceptive patch (n=251) for four consecutive menstrual cycles, starting with their next menses. Participants returned for a single follow-up visit during the fourth cycle for an evaluation, which included a questionnaire to assess acceptability and adverse effects. RESULTS: Rates of completion of three cycles were 94.6% (95% confidence interval [CI] 91.0-97.1%) and 88.2% (95% CI 83.4-92.0%) for ring and patch users, respectively (P=.03). Of these women, 71.0% (95% CI 64.8-76.6%) and 26.5% (95% CI 21.0-32.6%), respectively, planned to continue their method after the study (P<.001). Women switching to the patch were significantly more likely than women switching to the ring to experience longer periods (38% compared with 9%), increased dysmenorrhea (29% compared with 16%), frequent nausea (8% compared with 1%), frequent mood swings (14% compared with 8%), and frequent skin rash (12% compared with 2%) and were less likely to experience frequent vaginal discharge (8% compared with 17%). Ring users preferred the ring to the oral contraceptive (P<.001), and patch users preferred the oral contraceptive to the patch (P<.001). Nugent scores increased only in patch users (P=.01), although most of these women were asymptomatic. CONCLUSION: Women satisfied with combined oral contraceptives and interested in a nondaily method are more likely to continue using the contraceptive ring than the contraceptive patch. CLINICAL TRIAL REGISTRATION: ClinicalTrials.gov, www.clinicaltrials.gov, NCT00269620.

Original languageEnglish (US)
Pages (from-to)267-277
Number of pages11
JournalObstetrics and Gynecology
Volume111
Issue number2 PART 1
DOIs
StatePublished - Feb 2008
Externally publishedYes

ASJC Scopus subject areas

  • Obstetrics and Gynecology

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    Creinin, M. D., Meyn, L. A., Borgatta, L., Barnhart, K., Jensen, J., Burke, A. E., Westhoff, C., Gilliam, M., Dutton, C., & Ballagh, S. A. (2008). Multicenter comparison of the contraceptive ring and patch: A randomized controlled trial. Obstetrics and Gynecology, 111(2 PART 1), 267-277. https://doi.org/10.1097/01.AOG.0000298338.58511.d1