Multi-system inflammatory syndrome in children (Mis-c) following sars-cov-2 infection: Review of clinical presentation, hypothetical pathogenesis, and proposed management

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140 Scopus citations

Abstract

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection may result in the multisystem inflammatory syndrome in children (MIS-C). The clinical presentation of MIS-C includes fever, severe illness, and the involvement of two or more organ systems, in combination with laboratory evidence of inflammation and laboratory or epidemiologic evidence of SARS-CoV-2 infection. Some features of MIS-C resemble Kawasaki Disease, toxic shock syndrome, and secondary hemophagocytic lymphohistiocytosis/macrophage activation syndrome. The relationship of MIS-C to SARS-CoV-2 infection suggests that the pathogenesis involves post-infectious immune dysregulation. Patients with MIS-C should ideally be managed in a pediatric intensive care environment since rapid clinical deterioration may occur. Specific immunomodulatory therapy depends on the clinical presentation. The relationship between the immune response to SARS-CoV-2 vaccines in development and MIS-C requires further study.

Original languageEnglish (US)
Article number69
JournalChildren
Volume7
Issue number7
DOIs
StatePublished - Jul 2020

Keywords

  • COVID-19
  • Hemophagocytic lymphohistiocytosis
  • Kawasaki Disease
  • Macrophage activation syndrome
  • Multisystem inflammatory syndrome in children (MIS-C)
  • SARS-CoV-2
  • Toxic shock syndrome

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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