Abstract
Abstract. Shacklett BL, Critchfield JW, Ferre AL, Hayes TL (University of California, Davis, CA, USA). Mucosal T-cell responses to HIV: responding at the front lines (Review). J Intern Med 2008; 265: 58-66. Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4+ T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanisms, including secreted antibodies and CD8+ cytotoxic T cells (CTL). CTL in mucosal lymphoid tissues may serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naïve host. This review summarizes recent literature on HIV-specific T-cell responses in mucosal tissues, with an emphasis on the gastrointestinal tract.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 58-66 |
| Number of pages | 9 |
| Journal | Journal of Internal Medicine |
| Volume | 265 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2009 |
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Keywords
- Cytokine
- Cytotoxic T cells
- Gut
- T
ASJC Scopus subject areas
- Internal Medicine
Cite this
Mucosal T-cell responses to HIV : Responding at the front lines. / Shacklett, Barbara; Critchfield, J. W.; Ferre, A. L.; Hayes, T. L.
In: Journal of Internal Medicine, Vol. 265, No. 1, 01.2009, p. 58-66.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mucosal T-cell responses to HIV
T2 - Responding at the front lines
AU - Shacklett, Barbara
AU - Critchfield, J. W.
AU - Ferre, A. L.
AU - Hayes, T. L.
PY - 2009/1
Y1 - 2009/1
N2 - Abstract. Shacklett BL, Critchfield JW, Ferre AL, Hayes TL (University of California, Davis, CA, USA). Mucosal T-cell responses to HIV: responding at the front lines (Review). J Intern Med 2008; 265: 58-66. Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4+ T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanisms, including secreted antibodies and CD8+ cytotoxic T cells (CTL). CTL in mucosal lymphoid tissues may serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naïve host. This review summarizes recent literature on HIV-specific T-cell responses in mucosal tissues, with an emphasis on the gastrointestinal tract.
AB - Abstract. Shacklett BL, Critchfield JW, Ferre AL, Hayes TL (University of California, Davis, CA, USA). Mucosal T-cell responses to HIV: responding at the front lines (Review). J Intern Med 2008; 265: 58-66. Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4+ T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanisms, including secreted antibodies and CD8+ cytotoxic T cells (CTL). CTL in mucosal lymphoid tissues may serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naïve host. This review summarizes recent literature on HIV-specific T-cell responses in mucosal tissues, with an emphasis on the gastrointestinal tract.
KW - Cytokine
KW - Cytotoxic T cells
KW - Gut
KW - T
UR - http://www.scopus.com/inward/record.url?scp=57449093586&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=57449093586&partnerID=8YFLogxK
U2 - 10.1111/j.1365-2796.2008.02042.x
DO - 10.1111/j.1365-2796.2008.02042.x
M3 - Article
C2 - 19093960
AN - SCOPUS:57449093586
VL - 265
SP - 58
EP - 66
JO - Journal of Internal Medicine
JF - Journal of Internal Medicine
SN - 0954-6820
IS - 1
ER -