Mucosal T-cell responses to HIV: Responding at the front lines

Barbara Shacklett, J. W. Critchfield, A. L. Ferre, T. L. Hayes

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Abstract. Shacklett BL, Critchfield JW, Ferre AL, Hayes TL (University of California, Davis, CA, USA). Mucosal T-cell responses to HIV: responding at the front lines (Review). J Intern Med 2008; 265: 58-66. Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4+ T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanisms, including secreted antibodies and CD8+ cytotoxic T cells (CTL). CTL in mucosal lymphoid tissues may serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naïve host. This review summarizes recent literature on HIV-specific T-cell responses in mucosal tissues, with an emphasis on the gastrointestinal tract.

Original languageEnglish (US)
Pages (from-to)58-66
Number of pages9
JournalJournal of Internal Medicine
Issue number1
StatePublished - Jan 2009


  • Cytokine
  • Cytotoxic T cells
  • Gut
  • T

ASJC Scopus subject areas

  • Internal Medicine


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