Abstract
Abstract. Shacklett BL, Critchfield JW, Ferre AL, Hayes TL (University of California, Davis, CA, USA). Mucosal T-cell responses to HIV: responding at the front lines (Review). J Intern Med 2008; 265: 58-66. Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4+ T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanisms, including secreted antibodies and CD8+ cytotoxic T cells (CTL). CTL in mucosal lymphoid tissues may serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naïve host. This review summarizes recent literature on HIV-specific T-cell responses in mucosal tissues, with an emphasis on the gastrointestinal tract.
Original language | English (US) |
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Pages (from-to) | 58-66 |
Number of pages | 9 |
Journal | Journal of Internal Medicine |
Volume | 265 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2009 |
Keywords
- Cytokine
- Cytotoxic T cells
- Gut
- T
ASJC Scopus subject areas
- Internal Medicine