Mucosal T-cell responses to HIV: Responding at the front lines

Abstract. Shacklett BL, Critchfield JW, Ferre AL, Hayes TL (University of California, Davis, CA, USA). Mucosal T-cell responses to HIV: responding at the front lines (Review). J Intern Med 2008; 265: 58-66. Mucosal surfaces of the body serve as the major portal of entry for human immunodeficiency virus (HIV). These tissues also house a majority of the body's lymphocytes, including the CD4⁺ T cells that are the major cellular target for HIV infection. Mucosal surfaces are defended by innate and adaptive immune mechanisms, including secreted antibodies and CD8⁺ cytotoxic T cells (CTL). CTL in mucosal lymphoid tissues may serve to limit viral replication, decreasing the host's viral burden as well as reducing the likelihood of sexual transmission to a naïve host. This review summarizes recent literature on HIV-specific T-cell responses in mucosal tissues, with an emphasis on the gastrointestinal tract.