Mucosal immunization with live recombinant bovine respiratory syncytial virus (BRSV) and recombinant BRSV lacking the envelope glycoprotein G protects against challenge with wild-type BRSV

Ulrike Schmidt, Jörg Beyer, Ulf Polster, Laurel J Gershwin, Ursula J. Buchholz

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Recombinant bovine respiratory syncytial virus (rBRSV) and an rBRSV deletion mutant lacking the G gene (rBRSVΔG) were characterized in calves with respect to replication competence, attenuation, and protective efficacy as live-attenuated BRSV vaccines. Both recombinant viruses were safe and induced protection against a BRSV challenge infection. rBRSV replicated efficiently in the upper respiratory tract. Intranasal immunization with rBRSVΔG led to infection but not to mucosal virus replication. Neutralizing antibodies were induced by rBRSV and rBRSVΔG. Thus, the BRSV attachment glycoprotein G seems to be dispensable in vaccinating calves against BRSV.

Original languageEnglish (US)
Pages (from-to)12355-12359
Number of pages5
JournalJournal of Virology
Volume76
Issue number23
DOIs
StatePublished - Dec 2002
Externally publishedYes

ASJC Scopus subject areas

  • Immunology

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