Mucosal immunization with a live, virulence-attenuated simian immunodeficiency virus (SIV) vaccine elicits antiviral cytotoxic T lymphocytes and antibodies in rhesus macaques.

B. L. Lohman, M. B. McChesney, Chris J Miller, M. Otsyula, C. J. Berardi, Marta Marthas

Research output: Contribution to journalArticle

14 Scopus citations

Abstract

An effective AIDS vaccine must protect against sexual transmission of human immunodeficiency virus (HIV). Therefore, vaccine regimens which stimulate antiviral immunity in the genital tract as well as in peripheral blood and systemic lymphoid tissues are needed. Here, we describe a method of immunization by direct inoculation of the vaginal submucosa with a live attenuated SIV, SIVmac1A11. Immunization by this route generated low levels of SIV-specific IgG and IgA antibodies in serum and vaginal secretions and viral specific cytotoxic T lymphocyte (CTL) activity in peripheral blood.

Original languageEnglish (US)
Pages (from-to)95-101
Number of pages7
JournalJournal of Medical Primatology
Volume23
Issue number2-3
StatePublished - Feb 1994

ASJC Scopus subject areas

  • Animal Science and Zoology
  • veterinary(all)

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