Mucosal immunity in HIV/SIV infection: T Cells, B cells and beyond

Research output: Contribution to journalReview article

1 Citation (Scopus)

Abstract

As our understanding of mucosal immunity increases, it is becoming clear that the host response to HIV-1 is more complex and nuanced than originally believed. The mucosal landscape is populated with a variety of specialized cell types whose functions include combating infectious agents while preserving commensal microbiota, maintaining barrier integrity, and ensuring immune homeostasis. Advances in multiparameter flow cytometry, gene expression analysis and bioinformatics have allowed more detailed characterization of these cell types and their roles in host defense than was previously possible. This review provides an overview of existing literature on immunity to HIV-1 and SIVmac in mucosal tissues of the female reproductive tract and the gastrointestinal tract, focusing on major effector cell populations and briefly summarizing new information on tissue-resident memory T cells, Treg, Th17, Th22 and innate lymphocytes (ILC), subsets that have been studied primarily in the gastrointestinal mucosa.

Original languageEnglish (US)
Pages (from-to)63-75
Number of pages13
JournalCurrent Immunology Reviews
Volume15
Issue number1
DOIs
StatePublished - Jan 1 2019

Fingerprint

Mucosal Immunity
HIV Infections
B-Lymphocytes
T-Lymphocytes
HIV-1
Mucous Membrane
Microbiota
Lymphocyte Subsets
Computational Biology
Gastrointestinal Tract
Immunity
Flow Cytometry
Homeostasis
Gene Expression
Population

Keywords

  • Adaptive
  • Gut
  • HIV-1
  • Innate
  • Mucosa
  • SIV
  • T-cell

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

Cite this

Mucosal immunity in HIV/SIV infection : T Cells, B cells and beyond. / Shacklett, Barbara.

In: Current Immunology Reviews, Vol. 15, No. 1, 01.01.2019, p. 63-75.

Research output: Contribution to journalReview article

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