Mucosal immunity in HIV infection: What can be done to restore gastrointestinal-associated lymphoid tissue function?

Michael D. George, David Asmuth

Research output: Contribution to journalArticle

11 Scopus citations

Abstract

PURPOSE OF REVIEW: This review describes the impact of HIV infection on gut-associated lymphoid tissue, the mechanisms for persistent gut-associated lymphoid tissue dysfunction despite effective antiretroviral therapy, and potential strategies to restore gut-associated lymphoid tissue function and promote immune reconstitution. RECENT FINDINGS: Recent studies indicate that unresolved microbial translocation and intestinal dysbiosis may continue to promote enteropathy as well as HIV-associated and non-HIV-associated conditions in many HIV patients who otherwise maintain therapeutic control of systemic viral replication. SUMMARY: Several novel therapeutic approaches to reduce intestinal inflammation and mitigate microbial translocation may hold promise for restoring gastrointestinal health and thereby increasing the efficacy of immune reconstitution in HIV-infected patients undergoing antiretroviral therapy.

Original languageEnglish (US)
Pages (from-to)275-281
Number of pages7
JournalCurrent Opinion in Infectious Diseases
Volume27
Issue number3
DOIs
StatePublished - 2014

Keywords

  • dysbiosis
  • gut-associated lymphoid tissue
  • HIV-enteropathy
  • microbial translocation

ASJC Scopus subject areas

  • Microbiology (medical)
  • Infectious Diseases
  • Medicine(all)

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