Abstract
PURPOSE OF REVIEW: This review describes the impact of HIV infection on gut-associated lymphoid tissue, the mechanisms for persistent gut-associated lymphoid tissue dysfunction despite effective antiretroviral therapy, and potential strategies to restore gut-associated lymphoid tissue function and promote immune reconstitution. RECENT FINDINGS: Recent studies indicate that unresolved microbial translocation and intestinal dysbiosis may continue to promote enteropathy as well as HIV-associated and non-HIV-associated conditions in many HIV patients who otherwise maintain therapeutic control of systemic viral replication. SUMMARY: Several novel therapeutic approaches to reduce intestinal inflammation and mitigate microbial translocation may hold promise for restoring gastrointestinal health and thereby increasing the efficacy of immune reconstitution in HIV-infected patients undergoing antiretroviral therapy.
Original language | English (US) |
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Pages (from-to) | 275-281 |
Number of pages | 7 |
Journal | Current Opinion in Infectious Diseases |
Volume | 27 |
Issue number | 3 |
DOIs | |
State | Published - 2014 |
Keywords
- dysbiosis
- gut-associated lymphoid tissue
- HIV-enteropathy
- microbial translocation
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
- Medicine(all)