Abstract
PURPOSE OF REVIEW: This review describes the impact of HIV infection on gut-associated lymphoid tissue, the mechanisms for persistent gut-associated lymphoid tissue dysfunction despite effective antiretroviral therapy, and potential strategies to restore gut-associated lymphoid tissue function and promote immune reconstitution. RECENT FINDINGS: Recent studies indicate that unresolved microbial translocation and intestinal dysbiosis may continue to promote enteropathy as well as HIV-associated and non-HIV-associated conditions in many HIV patients who otherwise maintain therapeutic control of systemic viral replication. SUMMARY: Several novel therapeutic approaches to reduce intestinal inflammation and mitigate microbial translocation may hold promise for restoring gastrointestinal health and thereby increasing the efficacy of immune reconstitution in HIV-infected patients undergoing antiretroviral therapy.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 275-281 |
| Number of pages | 7 |
| Journal | Current Opinion in Infectious Diseases |
| Volume | 27 |
| Issue number | 3 |
| DOIs | |
| State | Published - 2014 |
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Keywords
- dysbiosis
- gut-associated lymphoid tissue
- HIV-enteropathy
- microbial translocation
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
- Medicine(all)
Cite this
Mucosal immunity in HIV infection : What can be done to restore gastrointestinal-associated lymphoid tissue function? / George, Michael D.; Asmuth, David.
In: Current Opinion in Infectious Diseases, Vol. 27, No. 3, 2014, p. 275-281.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mucosal immunity in HIV infection
T2 - What can be done to restore gastrointestinal-associated lymphoid tissue function?
AU - George, Michael D.
AU - Asmuth, David
PY - 2014
Y1 - 2014
N2 - PURPOSE OF REVIEW: This review describes the impact of HIV infection on gut-associated lymphoid tissue, the mechanisms for persistent gut-associated lymphoid tissue dysfunction despite effective antiretroviral therapy, and potential strategies to restore gut-associated lymphoid tissue function and promote immune reconstitution. RECENT FINDINGS: Recent studies indicate that unresolved microbial translocation and intestinal dysbiosis may continue to promote enteropathy as well as HIV-associated and non-HIV-associated conditions in many HIV patients who otherwise maintain therapeutic control of systemic viral replication. SUMMARY: Several novel therapeutic approaches to reduce intestinal inflammation and mitigate microbial translocation may hold promise for restoring gastrointestinal health and thereby increasing the efficacy of immune reconstitution in HIV-infected patients undergoing antiretroviral therapy.
AB - PURPOSE OF REVIEW: This review describes the impact of HIV infection on gut-associated lymphoid tissue, the mechanisms for persistent gut-associated lymphoid tissue dysfunction despite effective antiretroviral therapy, and potential strategies to restore gut-associated lymphoid tissue function and promote immune reconstitution. RECENT FINDINGS: Recent studies indicate that unresolved microbial translocation and intestinal dysbiosis may continue to promote enteropathy as well as HIV-associated and non-HIV-associated conditions in many HIV patients who otherwise maintain therapeutic control of systemic viral replication. SUMMARY: Several novel therapeutic approaches to reduce intestinal inflammation and mitigate microbial translocation may hold promise for restoring gastrointestinal health and thereby increasing the efficacy of immune reconstitution in HIV-infected patients undergoing antiretroviral therapy.
KW - dysbiosis
KW - gut-associated lymphoid tissue
KW - HIV-enteropathy
KW - microbial translocation
UR - http://www.scopus.com/inward/record.url?scp=84900512579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84900512579&partnerID=8YFLogxK
U2 - 10.1097/QCO.0000000000000059
DO - 10.1097/QCO.0000000000000059
M3 - Article
C2 - 24739345
AN - SCOPUS:84900512579
VL - 27
SP - 275
EP - 281
JO - Current Opinion in Infectious Diseases
JF - Current Opinion in Infectious Diseases
SN - 0951-7375
IS - 3
ER -