Mucosal immunity in HIV controllers

The right place at the right time

Barbara Shacklett, April L. Ferre

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose of review: The phenomenon of long-term nonprogression in HIV infection has been recognized for some time, and the ability of rare individuals, designated 'elite controllers', to control HIV in the absence of therapy is the focus of numerous ongoing studies. This review focuses on studies of HIV-specific immune responses in mucosal tissues as a potential correlate of immune control, with an emphasis on recently published work. Recent findings: Genetic studies have implicated a role for elements localized to the major histocompatibility complex (MHC) on chromosome 6 in the immune control of HIV infection. In parallel, functional studies have strongly implicated MHC class I-restricted, CD8 T-cell responses as a major contributor to elite control. In addition, the localization of HIV-specific CD8 and CD4 T cells with respect to the major sites of virus replication in the body may be critical in determining clinical outcome. Summary: Recent findings suggest that MHC class I-restricted, CD8 T cells are a major component of immune control in 'elite controllers'. In addition, the presence of these effector cells at or near critical viral reservoirs, such as mucosal tissues, may be critical in determining their effectiveness at limiting viral replication and dissemination.

Original languageEnglish (US)
Pages (from-to)202-207
Number of pages6
JournalCurrent Opinion in HIV and AIDS
Volume6
Issue number3
DOIs
StatePublished - May 2011

Fingerprint

Mucosal Immunity
Major Histocompatibility Complex
HIV
T-Lymphocytes
HIV Infections
Mucous Membrane
Chromosomes, Human, Pair 6
Virus Replication
Therapeutics

Keywords

  • cytotoxic T cells
  • GALT
  • gut
  • mucosal immunity
  • T-cell

ASJC Scopus subject areas

  • Hematology
  • Oncology(nursing)
  • Immunology
  • Infectious Diseases
  • Virology
  • Oncology

Cite this

Mucosal immunity in HIV controllers : The right place at the right time. / Shacklett, Barbara; Ferre, April L.

In: Current Opinion in HIV and AIDS, Vol. 6, No. 3, 05.2011, p. 202-207.

Research output: Contribution to journalArticle

@article{58521a511d25410491a2093220cda5d9,
title = "Mucosal immunity in HIV controllers: The right place at the right time",
abstract = "Purpose of review: The phenomenon of long-term nonprogression in HIV infection has been recognized for some time, and the ability of rare individuals, designated 'elite controllers', to control HIV in the absence of therapy is the focus of numerous ongoing studies. This review focuses on studies of HIV-specific immune responses in mucosal tissues as a potential correlate of immune control, with an emphasis on recently published work. Recent findings: Genetic studies have implicated a role for elements localized to the major histocompatibility complex (MHC) on chromosome 6 in the immune control of HIV infection. In parallel, functional studies have strongly implicated MHC class I-restricted, CD8 T-cell responses as a major contributor to elite control. In addition, the localization of HIV-specific CD8 and CD4 T cells with respect to the major sites of virus replication in the body may be critical in determining clinical outcome. Summary: Recent findings suggest that MHC class I-restricted, CD8 T cells are a major component of immune control in 'elite controllers'. In addition, the presence of these effector cells at or near critical viral reservoirs, such as mucosal tissues, may be critical in determining their effectiveness at limiting viral replication and dissemination.",
keywords = "cytotoxic T cells, GALT, gut, mucosal immunity, T-cell",
author = "Barbara Shacklett and Ferre, {April L.}",
year = "2011",
month = "5",
doi = "10.1097/COH.0b013e3283453e2b",
language = "English (US)",
volume = "6",
pages = "202--207",
journal = "Current Opinion in HIV and AIDS",
issn = "1746-630X",
publisher = "Lippincott Williams and Wilkins",
number = "3",

}

TY - JOUR

T1 - Mucosal immunity in HIV controllers

T2 - The right place at the right time

AU - Shacklett, Barbara

AU - Ferre, April L.

PY - 2011/5

Y1 - 2011/5

N2 - Purpose of review: The phenomenon of long-term nonprogression in HIV infection has been recognized for some time, and the ability of rare individuals, designated 'elite controllers', to control HIV in the absence of therapy is the focus of numerous ongoing studies. This review focuses on studies of HIV-specific immune responses in mucosal tissues as a potential correlate of immune control, with an emphasis on recently published work. Recent findings: Genetic studies have implicated a role for elements localized to the major histocompatibility complex (MHC) on chromosome 6 in the immune control of HIV infection. In parallel, functional studies have strongly implicated MHC class I-restricted, CD8 T-cell responses as a major contributor to elite control. In addition, the localization of HIV-specific CD8 and CD4 T cells with respect to the major sites of virus replication in the body may be critical in determining clinical outcome. Summary: Recent findings suggest that MHC class I-restricted, CD8 T cells are a major component of immune control in 'elite controllers'. In addition, the presence of these effector cells at or near critical viral reservoirs, such as mucosal tissues, may be critical in determining their effectiveness at limiting viral replication and dissemination.

AB - Purpose of review: The phenomenon of long-term nonprogression in HIV infection has been recognized for some time, and the ability of rare individuals, designated 'elite controllers', to control HIV in the absence of therapy is the focus of numerous ongoing studies. This review focuses on studies of HIV-specific immune responses in mucosal tissues as a potential correlate of immune control, with an emphasis on recently published work. Recent findings: Genetic studies have implicated a role for elements localized to the major histocompatibility complex (MHC) on chromosome 6 in the immune control of HIV infection. In parallel, functional studies have strongly implicated MHC class I-restricted, CD8 T-cell responses as a major contributor to elite control. In addition, the localization of HIV-specific CD8 and CD4 T cells with respect to the major sites of virus replication in the body may be critical in determining clinical outcome. Summary: Recent findings suggest that MHC class I-restricted, CD8 T cells are a major component of immune control in 'elite controllers'. In addition, the presence of these effector cells at or near critical viral reservoirs, such as mucosal tissues, may be critical in determining their effectiveness at limiting viral replication and dissemination.

KW - cytotoxic T cells

KW - GALT

KW - gut

KW - mucosal immunity

KW - T-cell

UR - http://www.scopus.com/inward/record.url?scp=79955472276&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=79955472276&partnerID=8YFLogxK

U2 - 10.1097/COH.0b013e3283453e2b

DO - 10.1097/COH.0b013e3283453e2b

M3 - Article

VL - 6

SP - 202

EP - 207

JO - Current Opinion in HIV and AIDS

JF - Current Opinion in HIV and AIDS

SN - 1746-630X

IS - 3

ER -