Mucosal immune responses to SIV infection

Chris J Miller, Michael B. McChesney, Xusheng Lü

Research output: Contribution to journalArticlepeer-review

8 Scopus citations


We have begun the process of characterizing the mucosal immune responses to SIV in the SIV/rhesus macaque system. We demonstrate that anti-SIV antibodies are found in the vaginal secretions, rectal secretions, saliva and serum of SIV-infected rhesus macaques and that IgG is the major anti-SIV antibody isotype in vaginal secretions and saliva. We have provided the first demonstration that anti-SIV cytotoxic T lymphocytes are present in the vaginal epithelium of SIV-infected rhesus macaques. The work described here clearly shows the existence of both cellular and humoral anti-SIV immune responses in the genital tract of SIV-infected female rhesus macaques.

Original languageEnglish (US)
Pages (from-to)139-145
Number of pages7
JournalSeminars in Virology
Issue number2
StatePublished - Apr 1996


  • Female genital tract
  • Saliva

ASJC Scopus subject areas

  • Immunology
  • Virology


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