Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas

Luis Carvajal-Carmona, Ann G. Zauber, Angela M. Jones, Kimberley Howarth, Jiping Wang, Timothy Cheng, Robert Riddell, Angel Lanas, Dion Morton, Monica M. Bertagnolli, Ian Tomlinson

Research output: Contribution to journalArticle

30 Scopus citations

Abstract

Several single-nucleotide polymorphisms (SNPs) have been associated with colorectal cancer (CRC) susceptibility. Most CRCs arise from adenomas, and SNPs therefore might affect predisposition to CRC by increasing adenoma risk. We found that 8 of 18 known CRC-associated SNPs (rs10936599, rs6983267, rs10795668, rs3802842, rs4444235, rs1957636, rs4939827, and rs961253) were over-represented in CRC-free patients with adenomas, compared with controls. Ten other CRC-associated SNPs (rs6691170, rs6687758, rs16892766, rs7136702, rs11169552, rs4779584, rs9929218, rs10411210, rs4813802, and rs4925386) were not associated significantly with adenoma risk. Genetic susceptibility to CRC in the general population is likely to be mediated in part by predisposition to adenomas.

Original languageEnglish (US)
Pages (from-to)53-55
Number of pages3
JournalGastroenterology
Volume144
Issue number1
DOIs
StatePublished - Jan 2013
Externally publishedYes

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Keywords

  • Colorectal Adenomas
  • Colorectal Carcinoma
  • Common Polymorphisms
  • Intermediate Phenotype

ASJC Scopus subject areas

  • Gastroenterology

Cite this

Carvajal-Carmona, L., Zauber, A. G., Jones, A. M., Howarth, K., Wang, J., Cheng, T., Riddell, R., Lanas, A., Morton, D., Bertagnolli, M. M., & Tomlinson, I. (2013). Much of the genetic risk of colorectal cancer is likely to be mediated through susceptibility to adenomas. Gastroenterology, 144(1), 53-55. https://doi.org/10.1053/j.gastro.2012.09.016