mTORC1 in the Control of Myogenesis and Adult Skeletal Muscle Mass

Marita A. Wallace, David C. Hughes, Keith Baar

Research output: Chapter in Book/Report/Conference proceedingChapter

3 Scopus citations


Skeletal muscle size and function are determined by developmental processes, the regenerative capacity of the muscle, as well as by the balance between muscle protein synthesis (MPS) and degradation in adult tissue. The mechanistic (or mammalian) target of rapamycin (mTOR) complex 1 (mTORC1) is essential for all of these processes, controlling muscle from embryonic development all the way through hypertrophy in adult skeletal muscle. mTORC1 activity and its subsequent regulation of MPS and muscle mass can be stimulated through a variety of signaling cascades that balance growth signals from nutrients, growth factors, and mechanical load/resistance exercise with the metabolic state of the muscle. Extensive research over the past 15 years has improved our understanding of how mTORC1 controls skeletal muscle development, growth, and maintenance. This chapter describes these advances in the context of skeletal muscle mass and function.

Original languageEnglish (US)
Title of host publicationMolecules to Medicine with mTOR: Translating Critical Pathways into Novel Therapeutic Strategies
PublisherElsevier Inc.
Number of pages20
ISBN (Print)9780128027332
StatePublished - Feb 26 2016


  • Aging
  • Amino acids
  • Exercise
  • Hypertrophy
  • Regeneration

ASJC Scopus subject areas

  • Medicine(all)


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