MR T1ρ and T2 of meniscus after acute anterior cruciate ligament injuries

Amy Wang, Valentina Pedoia, Favian Su, Elijah Abramson, Martin Kretzschmar, Lorenzo Nardo, Thomas M. Link, Charles E. McCulloch, Chengshi Jin, C. Benjamin Ma, Xiaojuan Li

Research output: Contribution to journalArticlepeer-review

22 Scopus citations


Objective: To evaluate differences in meniscal T1ρ and T2 quantification in patients with acute anterior cruciate ligament (ACL) injuries and to determine correlations of these differences with MR morphological grading and patient-reported outcomes. Design: Bilateral knees of 52 patients with acute ACL injury and 20 healthy controls were scanned using 3 T magnetic resonance imaging (MRI) T1ρ and T2 mapping in this prospective study. Quantitative analysis of the meniscus was performed in anterior and posterior horns of the lateral and medial menisci. Morphological meniscal damage was assessed using modified whole-organ MRI scores (WORMS). Measurements were compared between injured, uninjured contralateral, and control knees using a mixed-effects regression model. Correlations between meniscal T1ρ/T2, WORMS and Knee Injury and Osteoarthritis Outcome Scores (KOOS) were examined using partial correlation analysis. Results: Mean meniscal T1ρ and T2 values were significantly higher in ACL-injured knees compared to control and contralateral knees. Menisci of ACL-injured knees without tears, including those limited to modified meniscal WORMS grade 0, also had significantly higher T1ρ and T2 values compared to menisci of uninjured knees. Within ACL-injured knees, T1ρ and T2 values showed significant positive associations with meniscal WORMS and significant negative associations with KOOS. Conclusion: Acute ACL injuries are associated with significantly increased meniscal T1ρ and T2 values in both patients with and without meniscal lesions or tears, suggesting quantitative MRI provides more sensitive measures of meniscal differences compared to traditional morphological MRI sequences. Correlation between meniscal T1ρ/T2 and KOOS suggest that quantitative MRI is reflective of the extent of patients' clinical symptoms.

Original languageEnglish (US)
Pages (from-to)631-639
Number of pages9
JournalOsteoarthritis and Cartilage
Issue number4
StatePublished - Apr 1 2016
Externally publishedYes


  • Anterior cruciate ligament
  • Magnetic resonance imaging
  • Meniscus
  • Osteoarthritis
  • T1ρ
  • T2

ASJC Scopus subject areas

  • Rheumatology
  • Biomedical Engineering
  • Orthopedics and Sports Medicine


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