Abstract
Magnetic Resonance (MR)-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for controlling hyperthermia and local drug delivery. In this work, we developed a system capable of controlled tissue heating using proportional-integral-derivative (PID) feedback control combined with 7T MR thermometry for temperature feedback. MR thermometry was validated by an optical temperature probe. We have measured and simulated MR estimates of transient ultrasound-induced heating in a tofu phantom and performed controlled heating studies in an in vivo Met-1 mouse tumor. MR thermometry estimates agreed with fiber optic temperature measurements within 1°C, and simulations of heating in a tofu phantom were in agreement with the MR temperature measurement. MR-Acoustic Radiation Force Imaging (ARFI) was used to detect micron-scale displacement caused by acoustic radiation for beam localization in the absence of heating. The MRgFUS system developed here demonstrates adequate spatial and thermal accuracy for image-guided hyperthermia applications in small animals.
| Original language | English (US) |
|---|---|
| Title of host publication | IEEE International Ultrasonics Symposium, IUS |
| Pages | 1641-1644 |
| Number of pages | 4 |
| DOIs | |
| State | Published - 2011 |
| Event | 2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States Duration: Oct 18 2011 → Oct 21 2011 |
Other
| Other | 2011 IEEE International Ultrasonics Symposium, IUS 2011 |
|---|---|
| Country | United States |
| City | Orlando, FL |
| Period | 10/18/11 → 10/21/11 |
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Keywords
- FUS
- hyperthermia
- MR
- MR-ARFI
- thermal prediction
- thermometry
ASJC Scopus subject areas
- Acoustics and Ultrasonics
Cite this
MR-guided focused ultrasound with spatial and temporal temperature control for hyperthermia. / Liu, Yu; Fite, Brett Z.; Kruse, Dustin E.; Mahakian, Lisa; Dumont, Erik; Caskey, Charles F.; Ferrara, Katherine W.
IEEE International Ultrasonics Symposium, IUS. 2011. p. 1641-1644 6293417.Research output: Chapter in Book/Report/Conference proceeding › Conference contribution
}
TY - GEN
T1 - MR-guided focused ultrasound with spatial and temporal temperature control for hyperthermia
AU - Liu, Yu
AU - Fite, Brett Z.
AU - Kruse, Dustin E.
AU - Mahakian, Lisa
AU - Dumont, Erik
AU - Caskey, Charles F.
AU - Ferrara, Katherine W.
PY - 2011
Y1 - 2011
N2 - Magnetic Resonance (MR)-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for controlling hyperthermia and local drug delivery. In this work, we developed a system capable of controlled tissue heating using proportional-integral-derivative (PID) feedback control combined with 7T MR thermometry for temperature feedback. MR thermometry was validated by an optical temperature probe. We have measured and simulated MR estimates of transient ultrasound-induced heating in a tofu phantom and performed controlled heating studies in an in vivo Met-1 mouse tumor. MR thermometry estimates agreed with fiber optic temperature measurements within 1°C, and simulations of heating in a tofu phantom were in agreement with the MR temperature measurement. MR-Acoustic Radiation Force Imaging (ARFI) was used to detect micron-scale displacement caused by acoustic radiation for beam localization in the absence of heating. The MRgFUS system developed here demonstrates adequate spatial and thermal accuracy for image-guided hyperthermia applications in small animals.
AB - Magnetic Resonance (MR)-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for controlling hyperthermia and local drug delivery. In this work, we developed a system capable of controlled tissue heating using proportional-integral-derivative (PID) feedback control combined with 7T MR thermometry for temperature feedback. MR thermometry was validated by an optical temperature probe. We have measured and simulated MR estimates of transient ultrasound-induced heating in a tofu phantom and performed controlled heating studies in an in vivo Met-1 mouse tumor. MR thermometry estimates agreed with fiber optic temperature measurements within 1°C, and simulations of heating in a tofu phantom were in agreement with the MR temperature measurement. MR-Acoustic Radiation Force Imaging (ARFI) was used to detect micron-scale displacement caused by acoustic radiation for beam localization in the absence of heating. The MRgFUS system developed here demonstrates adequate spatial and thermal accuracy for image-guided hyperthermia applications in small animals.
KW - FUS
KW - hyperthermia
KW - MR
KW - MR-ARFI
KW - thermal prediction
KW - thermometry
UR - http://www.scopus.com/inward/record.url?scp=84869002572&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84869002572&partnerID=8YFLogxK
U2 - 10.1109/ULTSYM.2011.0408
DO - 10.1109/ULTSYM.2011.0408
M3 - Conference contribution
AN - SCOPUS:84869002572
SN - 9781457712531
SP - 1641
EP - 1644
BT - IEEE International Ultrasonics Symposium, IUS
ER -