MR-guided focused ultrasound with spatial and temporal temperature control for hyperthermia

Yu Liu; Brett Z. Fite; Dustin E. Kruse; Lisa Mahakian; Erik Dumont; Charles F. Caskey; Katherine W. Ferrara

doi:10.1109/ULTSYM.2011.0408

MR-guided focused ultrasound with spatial and temporal temperature control for hyperthermia

Yu Liu, Brett Z. Fite, Dustin E. Kruse, Lisa Mahakian, Erik Dumont, Charles F. Caskey, Katherine W. Ferrara

Biomedical Engineering

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Scopus citations

Abstract

Magnetic Resonance (MR)-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for controlling hyperthermia and local drug delivery. In this work, we developed a system capable of controlled tissue heating using proportional-integral-derivative (PID) feedback control combined with 7T MR thermometry for temperature feedback. MR thermometry was validated by an optical temperature probe. We have measured and simulated MR estimates of transient ultrasound-induced heating in a tofu phantom and performed controlled heating studies in an in vivo Met-1 mouse tumor. MR thermometry estimates agreed with fiber optic temperature measurements within 1°C, and simulations of heating in a tofu phantom were in agreement with the MR temperature measurement. MR-Acoustic Radiation Force Imaging (ARFI) was used to detect micron-scale displacement caused by acoustic radiation for beam localization in the absence of heating. The MRgFUS system developed here demonstrates adequate spatial and thermal accuracy for image-guided hyperthermia applications in small animals.

Original language	English (US)
Title of host publication	IEEE International Ultrasonics Symposium, IUS
Pages	1641-1644
Number of pages	4
DOIs	https://doi.org/10.1109/ULTSYM.2011.0408
State	Published - 2011
Event	2011 IEEE International Ultrasonics Symposium, IUS 2011 - Orlando, FL, United States Duration: Oct 18 2011 → Oct 21 2011

Other

Other	2011 IEEE International Ultrasonics Symposium, IUS 2011
Country/Territory	United States
City	Orlando, FL
Period	10/18/11 → 10/21/11

Keywords

FUS
hyperthermia
MR
MR-ARFI
thermal prediction
thermometry

ASJC Scopus subject areas

Acoustics and Ultrasonics

Access to Document

10.1109/ULTSYM.2011.0408

Cite this

MR-guided focused ultrasound with spatial and temporal temperature control for hyperthermia. / Liu, Yu; Fite, Brett Z.; Kruse, Dustin E.; Mahakian, Lisa; Dumont, Erik; Caskey, Charles F.; Ferrara, Katherine W.

IEEE International Ultrasonics Symposium, IUS. 2011. p. 1641-1644 6293417.

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

Liu, Y, Fite, BZ, Kruse, DE, Mahakian, L, Dumont, E, Caskey, CF & Ferrara, KW 2011, MR-guided focused ultrasound with spatial and temporal temperature control for hyperthermia. in IEEE International Ultrasonics Symposium, IUS., 6293417, pp. 1641-1644, 2011 IEEE International Ultrasonics Symposium, IUS 2011, Orlando, FL, United States, 10/18/11. https://doi.org/10.1109/ULTSYM.2011.0408

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title = "MR-guided focused ultrasound with spatial and temporal temperature control for hyperthermia",

abstract = "Magnetic Resonance (MR)-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for controlling hyperthermia and local drug delivery. In this work, we developed a system capable of controlled tissue heating using proportional-integral-derivative (PID) feedback control combined with 7T MR thermometry for temperature feedback. MR thermometry was validated by an optical temperature probe. We have measured and simulated MR estimates of transient ultrasound-induced heating in a tofu phantom and performed controlled heating studies in an in vivo Met-1 mouse tumor. MR thermometry estimates agreed with fiber optic temperature measurements within 1°C, and simulations of heating in a tofu phantom were in agreement with the MR temperature measurement. MR-Acoustic Radiation Force Imaging (ARFI) was used to detect micron-scale displacement caused by acoustic radiation for beam localization in the absence of heating. The MRgFUS system developed here demonstrates adequate spatial and thermal accuracy for image-guided hyperthermia applications in small animals.",

keywords = "FUS, hyperthermia, MR, MR-ARFI, thermal prediction, thermometry",

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doi = "10.1109/ULTSYM.2011.0408",

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AU - Dumont, Erik

AU - Caskey, Charles F.

AU - Ferrara, Katherine W.

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N2 - Magnetic Resonance (MR)-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for controlling hyperthermia and local drug delivery. In this work, we developed a system capable of controlled tissue heating using proportional-integral-derivative (PID) feedback control combined with 7T MR thermometry for temperature feedback. MR thermometry was validated by an optical temperature probe. We have measured and simulated MR estimates of transient ultrasound-induced heating in a tofu phantom and performed controlled heating studies in an in vivo Met-1 mouse tumor. MR thermometry estimates agreed with fiber optic temperature measurements within 1°C, and simulations of heating in a tofu phantom were in agreement with the MR temperature measurement. MR-Acoustic Radiation Force Imaging (ARFI) was used to detect micron-scale displacement caused by acoustic radiation for beam localization in the absence of heating. The MRgFUS system developed here demonstrates adequate spatial and thermal accuracy for image-guided hyperthermia applications in small animals.

AB - Magnetic Resonance (MR)-guided Focused Ultrasound (MRgFUS) is a promising non-invasive method for controlling hyperthermia and local drug delivery. In this work, we developed a system capable of controlled tissue heating using proportional-integral-derivative (PID) feedback control combined with 7T MR thermometry for temperature feedback. MR thermometry was validated by an optical temperature probe. We have measured and simulated MR estimates of transient ultrasound-induced heating in a tofu phantom and performed controlled heating studies in an in vivo Met-1 mouse tumor. MR thermometry estimates agreed with fiber optic temperature measurements within 1°C, and simulations of heating in a tofu phantom were in agreement with the MR temperature measurement. MR-Acoustic Radiation Force Imaging (ARFI) was used to detect micron-scale displacement caused by acoustic radiation for beam localization in the absence of heating. The MRgFUS system developed here demonstrates adequate spatial and thermal accuracy for image-guided hyperthermia applications in small animals.

KW - FUS

KW - hyperthermia

KW - MR

KW - MR-ARFI

KW - thermal prediction

KW - thermometry

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MR-guided focused ultrasound with spatial and temporal temperature control for hyperthermia

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Keywords

ASJC Scopus subject areas

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