MR-guided focused ultrasound surgery, present and future

David Schlesinger, Stanley H Benedict, Chris Diederich, Wladyslaw Gedroyc, Alexander Klibanov, James Larner

Research output: Contribution to journalArticlepeer-review

84 Scopus citations


MR-guided focused ultrasound surgery (MRgFUS) is a quickly developing technology with potential applications across a spectrum of indications traditionally within the domain of radiation oncology. Especially for applications where focal treatment is the preferred technique (for example, radiosurgery), MRgFUS has the potential to be a disruptive technology that could shift traditional patterns of care. While currently cleared in the United States for the noninvasive treatment of uterine fibroids and bone metastases, a wide range of clinical trials are currently underway, and the number of publications describing advances in MRgFUS is increasing. However, for MRgFUS to make the transition from a research curiosity to a clinical standard of care, a variety of challenges, technical, financial, clinical, and practical, must be overcome. This installment of the Vision 20/20 series examines the current status of MRgFUS, focusing on the hurdles the technology faces before it can cross over from a research technique to a standard fixture in the clinic. It then reviews current and near-term technical developments which may overcome these hurdles and allow MRgFUS to break through into clinical practice.

Original languageEnglish (US)
Article number080901
JournalMedical Physics
Issue number8
StatePublished - Aug 2013


  • ablative therapy
  • focused ultrasound surgery
  • HIFU
  • high-intensity ultrasound
  • minimally invasive therapy
  • neuromodulation
  • thermal therapy

ASJC Scopus subject areas

  • Biophysics
  • Radiology Nuclear Medicine and imaging
  • Medicine(all)


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