MR determination of glomerular filtration rate in subjects with solitary kidneys in comparison to clinical standards of renal function: Feasibility and preliminary report

Richard W Katzberg, Michael H Buonocore, Roger Low, Brian Hu, Kiran Jain, Michele Castillo, Scott Troxel, Mike M. Nguyen

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

This study was conducted to demonstrate the feasibility of quantifying single kidney glomerular filtration rate (skGFR) by magnetic resonance (MR) by comparison to the clinical estimates of GFR in volunteer subjects with a single kidney. Seven IRB-approved subjects with a solitary kidney, stable serum creatinine (SCr) and a 24 h creatinine clearance (CrCl) volunteered to undergo an MR examination that determined renal extraction fraction (EF) with a breathhold inversion recovery echo planar pulse sequence and renal blood flow with a velocity encoded phase imaging sequence. The product of EF and blood flow determines GFR. These values were compared with the 24 h CrCl, estimated GFR by the modification of diet in renal disease (MDRD) regression analysis and the Cockroft-Gault (CG) determination of CrCl. The mean and standard deviation of differences between the MR GFR, MDRD and CG vs the 24 h CrCl were 12.3±35.7, S8.9±18.5 and 1.2±19.6, respectively. The Student t-test showed that none of the mean differences were statistically significant between techniques. This clinical investigation shows that MR can be used for skGFR determination in human subjects with comparable values to those derived from clinically used serum-based GFR estimation techniques.

Original languageEnglish (US)
Pages (from-to)51-65
Number of pages15
JournalContrast Media and Molecular Imaging
Volume4
Issue number2
DOIs
StatePublished - 2009

Keywords

  • Gadolinium contrast media
  • Kidney function
  • Magnetic resonance imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'MR determination of glomerular filtration rate in subjects with solitary kidneys in comparison to clinical standards of renal function: Feasibility and preliminary report'. Together they form a unique fingerprint.

  • Cite this