Movement in ribosome translocation

Christopher S. Fraser, John W B Hershey

Research output: Contribution to journalArticle

3 Scopus citations

Abstract

Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G·GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-electron microscopy, this unexpected finding helps clarify the role of GTP in translocation.

Original languageEnglish (US)
Article number8
JournalJournal of Biology
Volume4
Issue number2
DOIs
StatePublished - 2005

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine(all)

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    Fraser, C. S., & Hershey, J. W. B. (2005). Movement in ribosome translocation. Journal of Biology, 4(2), [8]. https://doi.org/10.1186/jbiol27