Movement in ribosome translocation

Christopher S. Fraser, John W B Hershey

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G·GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-electron microscopy, this unexpected finding helps clarify the role of GTP in translocation.

Original languageEnglish (US)
Article number8
JournalJournal of Biology
Volume4
Issue number2
DOIs
StatePublished - 2005

Fingerprint

Peptide Elongation Factor G
Guanosine Triphosphate
ribosomes
Ribosomes
Cryoelectron Microscopy
Peptide Elongation Factors
Electron microscopy
Hydrolysis
protein synthesis
hydrolysis
Messenger RNA
Proteins

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)
  • Medicine(all)

Cite this

Fraser, C. S., & Hershey, J. W. B. (2005). Movement in ribosome translocation. Journal of Biology, 4(2), [8]. https://doi.org/10.1186/jbiol27

Movement in ribosome translocation. / Fraser, Christopher S.; Hershey, John W B.

In: Journal of Biology, Vol. 4, No. 2, 8, 2005.

Research output: Contribution to journalArticle

Fraser, CS & Hershey, JWB 2005, 'Movement in ribosome translocation', Journal of Biology, vol. 4, no. 2, 8. https://doi.org/10.1186/jbiol27
Fraser, Christopher S. ; Hershey, John W B. / Movement in ribosome translocation. In: Journal of Biology. 2005 ; Vol. 4, No. 2.
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