Movement in ribosome translocation

Christopher S. Fraser; John W B Hershey

doi:10.1186/jbiol27

Movement in ribosome translocation

Christopher S. Fraser, John W B Hershey

Molecular and Cellular Biology

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G·GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-electron microscopy, this unexpected finding helps clarify the role of GTP in translocation.

Original language	English (US)
Article number	8
Journal	Journal of Biology
Volume	4
Issue number	2
DOIs	https://doi.org/10.1186/jbiol27
State	Published - 2005

ASJC Scopus subject areas

Biochemistry, Genetics and Molecular Biology(all)
Agricultural and Biological Sciences(all)
Medicine(all)

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10.1186/jbiol27

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abstract = "Translocation of peptidyl-tRNA and mRNA within the ribosome during protein synthesis is promoted by the elongation factor EF-G and by the hydrolysis of GTP. A new study reports that EF-G binds to ribosomes as an EF-G·GDP complex and that GTP is exchanged for GDP on the ribosome. Together with cryo-electron microscopy, this unexpected finding helps clarify the role of GTP in translocation.",

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Movement in ribosome translocation

Abstract

ASJC Scopus subject areas

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