Movement disorders in the Hfe knockout mouse

Mari S. Golub, Stacey L. Germann, Renee S. Araiza, J. Rachel Reader, Stephen M Griffey, Kevin C K Lloyd

Research output: Contribution to journalArticle

24 Scopus citations

Abstract

The Hfe(-/-) mouse is a model for human hereditary hemochromatosis (HHH). The accumulation of tissue iron in this condition has led to the suggestion that HHH patients may be at higher risk for neurodegenerative diseases. In this study, adult male Hfe(-/-) mice and wildtype controls (n =12/group) were evaluated for impairment with motor tests (stride length, landing footsplay, rotarod) as well as a general observational battery (Functional Observational Battery, FOB). Hfe(-/-) mice were characterized by more falls from the rotarod, wider forelimb landing footsplay and hypersensitivity to proximal stimulation. Iron accumulation in brain was not detected by histopathology. These data suggest that a motor syndrome may be associated with HHH that could be further understood through the Hfe(-/-) mouse model.

Original languageEnglish (US)
Pages (from-to)239-244
Number of pages6
JournalNutritional Neuroscience
Volume8
Issue number4
DOIs
StatePublished - Aug 2005

Keywords

  • Hemochromatosis
  • Iron
  • Motor behavior
  • Parkinson's disease
  • Transgenic mouse

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Neuroscience(all)
  • Food Science

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