Abstract
Background: Parkinson's disease (PD), traditionally considered a movement disorder, has been shown to affect executive function such as the ability to adapt behavior in response to new environmental situations. Objective: to identify the impact of PD on neural substrates subserving two specific components of normal movement which we refer to as activation (initiating an un-cued response) and inhibition (suppressing a cued response). Methods: We used fMRI to measure pre-movement processes associated with activating an un-cued response and inhibiting a cued response plan in 13 PD (ON anti-parkinsonian medications) and 13 control subjects. Subjects were shown a visual arrow cue followed by a matched or mismatched response target that instructed them to respond with a right, left, or bilateral button press. In mismatched trials, an un-cued (new) response was initiated, or the previously cued response was suppressed. Results: We were able to isolate pre-movement responses in dorsolateral prefrontal cortex, specifically in the right hemisphere. During the activation of an un-cued movement, PD subjects showed decreased activity in the putamen and increased cortical activity in bilateral DLPFC, SMA, subcentral gyrus and inferior frontal operculum. During inhibition of a previously cued movement, the PD group showed increased activation in SMA, S1/M1, premotor and superior parietal areas. Conclusion: Right DLPFC plays a role in pre-movement processes, and DLPFC activity is abnormal in PD. Decreased specificity of responses was observed in multiple ROI's. The basal ganglia are involved in circuits that coordinate activation and inhibition involved in action selection as well as execution.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 181-192 |
| Number of pages | 12 |
| Journal | Journal of Parkinson's Disease |
| Volume | 3 |
| Issue number | 2 |
| DOIs | |
| State | Published - 2013 |
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Keywords
- dorsolateral prefrontal cortex
- Executive function
- fMRI
ASJC Scopus subject areas
- Clinical Neurology
- Cellular and Molecular Neuroscience
Cite this
Movement activation and inhibition in Parkinson's disease : A functional imaging study. / Disbrow, Elizabeth A.; Sigvardt, Karen A.; Franz, Elizabeth A.; Turner, Robert S.; Russo, Kim A.; Hinkley, Leighton B.; Herron, Timothy J.; Ventura, Maria I.; Zhang, Lin; Malhado-Chang, Norika O.
In: Journal of Parkinson's Disease, Vol. 3, No. 2, 2013, p. 181-192.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Movement activation and inhibition in Parkinson's disease
T2 - A functional imaging study
AU - Disbrow, Elizabeth A.
AU - Sigvardt, Karen A.
AU - Franz, Elizabeth A.
AU - Turner, Robert S.
AU - Russo, Kim A.
AU - Hinkley, Leighton B.
AU - Herron, Timothy J.
AU - Ventura, Maria I.
AU - Zhang, Lin
AU - Malhado-Chang, Norika O
PY - 2013
Y1 - 2013
N2 - Background: Parkinson's disease (PD), traditionally considered a movement disorder, has been shown to affect executive function such as the ability to adapt behavior in response to new environmental situations. Objective: to identify the impact of PD on neural substrates subserving two specific components of normal movement which we refer to as activation (initiating an un-cued response) and inhibition (suppressing a cued response). Methods: We used fMRI to measure pre-movement processes associated with activating an un-cued response and inhibiting a cued response plan in 13 PD (ON anti-parkinsonian medications) and 13 control subjects. Subjects were shown a visual arrow cue followed by a matched or mismatched response target that instructed them to respond with a right, left, or bilateral button press. In mismatched trials, an un-cued (new) response was initiated, or the previously cued response was suppressed. Results: We were able to isolate pre-movement responses in dorsolateral prefrontal cortex, specifically in the right hemisphere. During the activation of an un-cued movement, PD subjects showed decreased activity in the putamen and increased cortical activity in bilateral DLPFC, SMA, subcentral gyrus and inferior frontal operculum. During inhibition of a previously cued movement, the PD group showed increased activation in SMA, S1/M1, premotor and superior parietal areas. Conclusion: Right DLPFC plays a role in pre-movement processes, and DLPFC activity is abnormal in PD. Decreased specificity of responses was observed in multiple ROI's. The basal ganglia are involved in circuits that coordinate activation and inhibition involved in action selection as well as execution.
AB - Background: Parkinson's disease (PD), traditionally considered a movement disorder, has been shown to affect executive function such as the ability to adapt behavior in response to new environmental situations. Objective: to identify the impact of PD on neural substrates subserving two specific components of normal movement which we refer to as activation (initiating an un-cued response) and inhibition (suppressing a cued response). Methods: We used fMRI to measure pre-movement processes associated with activating an un-cued response and inhibiting a cued response plan in 13 PD (ON anti-parkinsonian medications) and 13 control subjects. Subjects were shown a visual arrow cue followed by a matched or mismatched response target that instructed them to respond with a right, left, or bilateral button press. In mismatched trials, an un-cued (new) response was initiated, or the previously cued response was suppressed. Results: We were able to isolate pre-movement responses in dorsolateral prefrontal cortex, specifically in the right hemisphere. During the activation of an un-cued movement, PD subjects showed decreased activity in the putamen and increased cortical activity in bilateral DLPFC, SMA, subcentral gyrus and inferior frontal operculum. During inhibition of a previously cued movement, the PD group showed increased activation in SMA, S1/M1, premotor and superior parietal areas. Conclusion: Right DLPFC plays a role in pre-movement processes, and DLPFC activity is abnormal in PD. Decreased specificity of responses was observed in multiple ROI's. The basal ganglia are involved in circuits that coordinate activation and inhibition involved in action selection as well as execution.
KW - dorsolateral prefrontal cortex
KW - Executive function
KW - fMRI
UR - http://www.scopus.com/inward/record.url?scp=84880235545&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84880235545&partnerID=8YFLogxK
U2 - 10.3233/JPD-130181
DO - 10.3233/JPD-130181
M3 - Article
C2 - 23938347
AN - SCOPUS:84880235545
VL - 3
SP - 181
EP - 192
JO - Journal of Parkinson's Disease
JF - Journal of Parkinson's Disease
SN - 1877-7171
IS - 2
ER -