Movement activation and inhibition in Parkinson's disease: A functional imaging study

Elizabeth A. Disbrow, Karen A. Sigvardt, Elizabeth A. Franz, Robert S. Turner, Kim A. Russo, Leighton B. Hinkley, Timothy J. Herron, Maria I. Ventura, Lin Zhang, Norika O Malhado-Chang

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Background: Parkinson's disease (PD), traditionally considered a movement disorder, has been shown to affect executive function such as the ability to adapt behavior in response to new environmental situations. Objective: to identify the impact of PD on neural substrates subserving two specific components of normal movement which we refer to as activation (initiating an un-cued response) and inhibition (suppressing a cued response). Methods: We used fMRI to measure pre-movement processes associated with activating an un-cued response and inhibiting a cued response plan in 13 PD (ON anti-parkinsonian medications) and 13 control subjects. Subjects were shown a visual arrow cue followed by a matched or mismatched response target that instructed them to respond with a right, left, or bilateral button press. In mismatched trials, an un-cued (new) response was initiated, or the previously cued response was suppressed. Results: We were able to isolate pre-movement responses in dorsolateral prefrontal cortex, specifically in the right hemisphere. During the activation of an un-cued movement, PD subjects showed decreased activity in the putamen and increased cortical activity in bilateral DLPFC, SMA, subcentral gyrus and inferior frontal operculum. During inhibition of a previously cued movement, the PD group showed increased activation in SMA, S1/M1, premotor and superior parietal areas. Conclusion: Right DLPFC plays a role in pre-movement processes, and DLPFC activity is abnormal in PD. Decreased specificity of responses was observed in multiple ROI's. The basal ganglia are involved in circuits that coordinate activation and inhibition involved in action selection as well as execution.

Original languageEnglish (US)
Pages (from-to)181-192
Number of pages12
JournalJournal of Parkinson's Disease
Volume3
Issue number2
DOIs
StatePublished - 2013

Fingerprint

Parkinson Disease
Prefrontal Cortex
Aptitude
Putamen
Executive Function
Movement Disorders
Basal Ganglia
Cues
Magnetic Resonance Imaging
Inhibition (Psychology)

Keywords

  • dorsolateral prefrontal cortex
  • Executive function
  • fMRI

ASJC Scopus subject areas

  • Clinical Neurology
  • Cellular and Molecular Neuroscience

Cite this

Disbrow, E. A., Sigvardt, K. A., Franz, E. A., Turner, R. S., Russo, K. A., Hinkley, L. B., ... Malhado-Chang, N. O. (2013). Movement activation and inhibition in Parkinson's disease: A functional imaging study. Journal of Parkinson's Disease, 3(2), 181-192. https://doi.org/10.3233/JPD-130181

Movement activation and inhibition in Parkinson's disease : A functional imaging study. / Disbrow, Elizabeth A.; Sigvardt, Karen A.; Franz, Elizabeth A.; Turner, Robert S.; Russo, Kim A.; Hinkley, Leighton B.; Herron, Timothy J.; Ventura, Maria I.; Zhang, Lin; Malhado-Chang, Norika O.

In: Journal of Parkinson's Disease, Vol. 3, No. 2, 2013, p. 181-192.

Research output: Contribution to journalArticle

Disbrow, EA, Sigvardt, KA, Franz, EA, Turner, RS, Russo, KA, Hinkley, LB, Herron, TJ, Ventura, MI, Zhang, L & Malhado-Chang, NO 2013, 'Movement activation and inhibition in Parkinson's disease: A functional imaging study', Journal of Parkinson's Disease, vol. 3, no. 2, pp. 181-192. https://doi.org/10.3233/JPD-130181
Disbrow, Elizabeth A. ; Sigvardt, Karen A. ; Franz, Elizabeth A. ; Turner, Robert S. ; Russo, Kim A. ; Hinkley, Leighton B. ; Herron, Timothy J. ; Ventura, Maria I. ; Zhang, Lin ; Malhado-Chang, Norika O. / Movement activation and inhibition in Parkinson's disease : A functional imaging study. In: Journal of Parkinson's Disease. 2013 ; Vol. 3, No. 2. pp. 181-192.
@article{8d4e7c238ec94492b2d582cb73d6a73b,
title = "Movement activation and inhibition in Parkinson's disease: A functional imaging study",
abstract = "Background: Parkinson's disease (PD), traditionally considered a movement disorder, has been shown to affect executive function such as the ability to adapt behavior in response to new environmental situations. Objective: to identify the impact of PD on neural substrates subserving two specific components of normal movement which we refer to as activation (initiating an un-cued response) and inhibition (suppressing a cued response). Methods: We used fMRI to measure pre-movement processes associated with activating an un-cued response and inhibiting a cued response plan in 13 PD (ON anti-parkinsonian medications) and 13 control subjects. Subjects were shown a visual arrow cue followed by a matched or mismatched response target that instructed them to respond with a right, left, or bilateral button press. In mismatched trials, an un-cued (new) response was initiated, or the previously cued response was suppressed. Results: We were able to isolate pre-movement responses in dorsolateral prefrontal cortex, specifically in the right hemisphere. During the activation of an un-cued movement, PD subjects showed decreased activity in the putamen and increased cortical activity in bilateral DLPFC, SMA, subcentral gyrus and inferior frontal operculum. During inhibition of a previously cued movement, the PD group showed increased activation in SMA, S1/M1, premotor and superior parietal areas. Conclusion: Right DLPFC plays a role in pre-movement processes, and DLPFC activity is abnormal in PD. Decreased specificity of responses was observed in multiple ROI's. The basal ganglia are involved in circuits that coordinate activation and inhibition involved in action selection as well as execution.",
keywords = "dorsolateral prefrontal cortex, Executive function, fMRI",
author = "Disbrow, {Elizabeth A.} and Sigvardt, {Karen A.} and Franz, {Elizabeth A.} and Turner, {Robert S.} and Russo, {Kim A.} and Hinkley, {Leighton B.} and Herron, {Timothy J.} and Ventura, {Maria I.} and Lin Zhang and Malhado-Chang, {Norika O}",
year = "2013",
doi = "10.3233/JPD-130181",
language = "English (US)",
volume = "3",
pages = "181--192",
journal = "Journal of Parkinson's Disease",
issn = "1877-7171",
publisher = "IOS Press",
number = "2",

}

TY - JOUR

T1 - Movement activation and inhibition in Parkinson's disease

T2 - A functional imaging study

AU - Disbrow, Elizabeth A.

AU - Sigvardt, Karen A.

AU - Franz, Elizabeth A.

AU - Turner, Robert S.

AU - Russo, Kim A.

AU - Hinkley, Leighton B.

AU - Herron, Timothy J.

AU - Ventura, Maria I.

AU - Zhang, Lin

AU - Malhado-Chang, Norika O

PY - 2013

Y1 - 2013

N2 - Background: Parkinson's disease (PD), traditionally considered a movement disorder, has been shown to affect executive function such as the ability to adapt behavior in response to new environmental situations. Objective: to identify the impact of PD on neural substrates subserving two specific components of normal movement which we refer to as activation (initiating an un-cued response) and inhibition (suppressing a cued response). Methods: We used fMRI to measure pre-movement processes associated with activating an un-cued response and inhibiting a cued response plan in 13 PD (ON anti-parkinsonian medications) and 13 control subjects. Subjects were shown a visual arrow cue followed by a matched or mismatched response target that instructed them to respond with a right, left, or bilateral button press. In mismatched trials, an un-cued (new) response was initiated, or the previously cued response was suppressed. Results: We were able to isolate pre-movement responses in dorsolateral prefrontal cortex, specifically in the right hemisphere. During the activation of an un-cued movement, PD subjects showed decreased activity in the putamen and increased cortical activity in bilateral DLPFC, SMA, subcentral gyrus and inferior frontal operculum. During inhibition of a previously cued movement, the PD group showed increased activation in SMA, S1/M1, premotor and superior parietal areas. Conclusion: Right DLPFC plays a role in pre-movement processes, and DLPFC activity is abnormal in PD. Decreased specificity of responses was observed in multiple ROI's. The basal ganglia are involved in circuits that coordinate activation and inhibition involved in action selection as well as execution.

AB - Background: Parkinson's disease (PD), traditionally considered a movement disorder, has been shown to affect executive function such as the ability to adapt behavior in response to new environmental situations. Objective: to identify the impact of PD on neural substrates subserving two specific components of normal movement which we refer to as activation (initiating an un-cued response) and inhibition (suppressing a cued response). Methods: We used fMRI to measure pre-movement processes associated with activating an un-cued response and inhibiting a cued response plan in 13 PD (ON anti-parkinsonian medications) and 13 control subjects. Subjects were shown a visual arrow cue followed by a matched or mismatched response target that instructed them to respond with a right, left, or bilateral button press. In mismatched trials, an un-cued (new) response was initiated, or the previously cued response was suppressed. Results: We were able to isolate pre-movement responses in dorsolateral prefrontal cortex, specifically in the right hemisphere. During the activation of an un-cued movement, PD subjects showed decreased activity in the putamen and increased cortical activity in bilateral DLPFC, SMA, subcentral gyrus and inferior frontal operculum. During inhibition of a previously cued movement, the PD group showed increased activation in SMA, S1/M1, premotor and superior parietal areas. Conclusion: Right DLPFC plays a role in pre-movement processes, and DLPFC activity is abnormal in PD. Decreased specificity of responses was observed in multiple ROI's. The basal ganglia are involved in circuits that coordinate activation and inhibition involved in action selection as well as execution.

KW - dorsolateral prefrontal cortex

KW - Executive function

KW - fMRI

UR - http://www.scopus.com/inward/record.url?scp=84880235545&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880235545&partnerID=8YFLogxK

U2 - 10.3233/JPD-130181

DO - 10.3233/JPD-130181

M3 - Article

C2 - 23938347

AN - SCOPUS:84880235545

VL - 3

SP - 181

EP - 192

JO - Journal of Parkinson's Disease

JF - Journal of Parkinson's Disease

SN - 1877-7171

IS - 2

ER -