Mouse Thioredoxin Gene Maps on Chromosome 4, whereas Its Pseudogene Maps on Chromosome 1

Makoto Taketo, Minoru Matsui, Julie M. Rochelle, Junji Yodoi, Michael F Seldin

Research output: Contribution to journalArticle

16 Scopus citations


Thioredoxins are involved in various biochemical systems and mediate both redox and nonredox functions. In mammalian cells, thioredoxin functions as an endogenous glucocorticoid receptor activating factor and as an adult T-cell leukemia-derived factor (ADF) that stimulates expression of interleukin-2 receptor in human T-cell leukemia virus (HTLV)-I transformed T cells. We have mapped the thioredoxin gene (Txn) and its processed pseudogene (Txn-ps1) in the mouse using a panel of interspecific backcross mice. Txn maps to Chr 4, whereas Txn-ps1 maps to the proximal region of Chr 1.

Original languageEnglish (US)
Pages (from-to)251-253
Number of pages3
Issue number1
StatePublished - May 1 1994
Externally publishedYes


ASJC Scopus subject areas

  • Genetics

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