Abstract
Autism is a neurodevelopmental disorder that is currently diagnosed by the presence of three behavioral criteria (1) qualitative impairments in reciprocal social interactions, (2) deficits in communication, including delayed language and noninteractive conversation, and (3) motor stereotypies, repetitive behaviors, insistence on sameness, and restricted interests. This chapter describes analogous behavioral assays that have been developed for mice, including tests for social approach, reciprocal social interactions, olfactory communication, ultrasonic vocalizations, repetitive and perseverative behaviors, and motor stereotypies. Examples of assay applications to genetic mouse models of autism are provided. Robust endophenotypes that are highly relevant to the core symptoms of autism are enabling the search for the genetic and environmental causes of autism, and the discovery of effective treatments.
| Original language | English (US) |
|---|---|
| Title of host publication | Current Topics in Behavioral Neurosciences |
| Pages | 187-212 |
| Number of pages | 26 |
| Volume | 7 |
| Edition | 1 |
| DOIs | |
| State | Published - 2011 |
| Externally published | Yes |
Publication series
| Name | Current Topics in Behavioral Neurosciences |
|---|---|
| Number | 1 |
| Volume | 7 |
| ISSN (Print) | 18663370 |
| ISSN (Electronic) | 18663389 |
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Keywords
- Autism
- Behavior
- Candidate genes
- Communication
- Genetics
- Mice
- Mouse models
- Olfactory
- Repetitive
- Social
- Vocalization
ASJC Scopus subject areas
- Behavioral Neuroscience
Cite this
Mouse models of autism : Testing hypotheses about molecular mechanisms. / Roullet, Florence I.; Crawley, Jacqueline.
Current Topics in Behavioral Neurosciences. Vol. 7 1. ed. 2011. p. 187-212 (Current Topics in Behavioral Neurosciences; Vol. 7, No. 1).Research output: Chapter in Book/Report/Conference proceeding › Chapter
}
TY - CHAP
T1 - Mouse models of autism
T2 - Testing hypotheses about molecular mechanisms
AU - Roullet, Florence I.
AU - Crawley, Jacqueline
PY - 2011
Y1 - 2011
N2 - Autism is a neurodevelopmental disorder that is currently diagnosed by the presence of three behavioral criteria (1) qualitative impairments in reciprocal social interactions, (2) deficits in communication, including delayed language and noninteractive conversation, and (3) motor stereotypies, repetitive behaviors, insistence on sameness, and restricted interests. This chapter describes analogous behavioral assays that have been developed for mice, including tests for social approach, reciprocal social interactions, olfactory communication, ultrasonic vocalizations, repetitive and perseverative behaviors, and motor stereotypies. Examples of assay applications to genetic mouse models of autism are provided. Robust endophenotypes that are highly relevant to the core symptoms of autism are enabling the search for the genetic and environmental causes of autism, and the discovery of effective treatments.
AB - Autism is a neurodevelopmental disorder that is currently diagnosed by the presence of three behavioral criteria (1) qualitative impairments in reciprocal social interactions, (2) deficits in communication, including delayed language and noninteractive conversation, and (3) motor stereotypies, repetitive behaviors, insistence on sameness, and restricted interests. This chapter describes analogous behavioral assays that have been developed for mice, including tests for social approach, reciprocal social interactions, olfactory communication, ultrasonic vocalizations, repetitive and perseverative behaviors, and motor stereotypies. Examples of assay applications to genetic mouse models of autism are provided. Robust endophenotypes that are highly relevant to the core symptoms of autism are enabling the search for the genetic and environmental causes of autism, and the discovery of effective treatments.
KW - Autism
KW - Behavior
KW - Candidate genes
KW - Communication
KW - Genetics
KW - Mice
KW - Mouse models
KW - Olfactory
KW - Repetitive
KW - Social
KW - Vocalization
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UR - http://www.scopus.com/inward/citedby.url?scp=81955161403&partnerID=8YFLogxK
U2 - 10.1007/7854_2010_113
DO - 10.1007/7854_2010_113
M3 - Chapter
C2 - 21225409
AN - SCOPUS:81955161403
SN - 9783642197024
VL - 7
T3 - Current Topics in Behavioral Neurosciences
SP - 187
EP - 212
BT - Current Topics in Behavioral Neurosciences
ER -