Mouse hepatitis virus nasoencephalopathy is dependent upon virus strain and host genotype

Stephen W Barthold, Deborah S. Beck, A. L. Smith

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

Mouse hepatitis virus (MHV) S induced typical MHV spongiform lesions in brainstem 28 days following intranasal inoculation of adult A/J, BALB/cByJ, CBA/J, C3H/HeJ and C3H/RV, but not SJL mice. In all but SJL mice, brain lesions occurred at or near the infectious dose level, based on seroconversion by the indirect immunofluorescence assay. During the acute phase of infection (day 5), lesions were limited to the nose and brain in most genotypes. Exceptions were BALB mice, which had mild hepatitis and SJL mice, which had lesions restricted to the nose. No mortality occurred in any genotype. Following intranasal inoculation of adult mice, MHV-1, -3, -A 59,-JHM and -S all caused brain lesions at 28 days after inoculation. MHV-1 and-3 caused lesions that were usually restricted to the anterior olfactory tracts, while MHV-A 59, -S and -JHM also caused more generalized and pronounced lesions involving the midbrain and pons. These studies suggest that avirulent MHV-S given intranasally to most mouse genotypes is a good model for induction of brain infection in the absence of mortality. They also confirm observations made by others in which MHV-JHM, -S and -A 59 are relatively more neurotropic than other MHV strains, such as MHV-1 and -3.

Original languageEnglish (US)
Pages (from-to)247-256
Number of pages10
JournalArchives of Virology
Volume91
Issue number3-4
DOIs
StatePublished - Sep 1986
Externally publishedYes

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Murine hepatitis virus
Genotype
Viruses
Brain
Nose
Pons
Mortality
Olfactory Bulb
Indirect Fluorescent Antibody Technique
Mesencephalon
Infection
Hepatitis
Brain Stem

ASJC Scopus subject areas

  • Applied Microbiology and Biotechnology
  • Genetics

Cite this

Mouse hepatitis virus nasoencephalopathy is dependent upon virus strain and host genotype. / Barthold, Stephen W; Beck, Deborah S.; Smith, A. L.

In: Archives of Virology, Vol. 91, No. 3-4, 09.1986, p. 247-256.

Research output: Contribution to journalArticle

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