Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains

Sheryl S. Moy, Jessica J. Nadler, Nancy B. Young, Antonio Perez, L. Paige Holloway, Ryan P. Barbaro, Justin R. Barbaro, Lindsay M. Wilson, David W. Threadgill, Jean M. Lauder, Terry R. Magnuson, Jacqueline Crawley

Research output: Contribution to journalArticle

490 Citations (Scopus)

Abstract

Three defining clinical symptoms of autism are aberrant reciprocal social interactions, deficits in social communication, and repetitive behaviors, including motor stereotypies and insistence on sameness. We developed a set of behavioral tasks designed to model components of these core symptoms in mice. Male mice from 10 inbred strains were characterized in assays for sociability, preference for social novelty, and reversal of the spatial location of the reinforcer in T-maze and Morris water maze tasks. Six strains, C57BL/6J, C57L/J, DBA/2J, FVB/NJ, C3H/HeJ, and AKR/J, showed significant levels of sociability, while A/J, BALB/cByJ, BTBR T+tf/J, and 129S1/SvImJ mice did not. C57BL/6J, C57L/J, DBA/2J, FVB/NJ, BALB/cByJ, and BTBR T+tf/J showed significant preference for social novelty, while C3H/HeJ, AKR/J, A/J, and 129S1/SvImJ did not. Normal scores on relevant control measures confirmed general health and physical abilities in all strains, ruling out artifactual explanations for social deficits. Elevated plus maze scores confirmed high anxiety-like behaviors in A/J, BALB/cByJ, and 129S1/SvImJ, which could underlie components of their low social approach. Strains that showed high levels of performance on acquisition of a T-maze task were also able to reach criterion for reversal learning. On the Morris water maze task, DBA/2J, AKR/J, BTBR T+tf/J, and 129S1/SvImJ failed to show significant quadrant preference during the reversal probe trial. These results highlight a dissociation between social task performance and reversal learning. BTBR T+tf/J is a particularly interesting strain, displaying both low social approach and resistance to change in routine on the water maze, consistent with an autism-like phenotype. Our multitask strategy for modeling symptoms of autism will be useful for investigating targeted and random gene mutations, QTLs, and microarray analyses.

Original languageEnglish (US)
Pages (from-to)4-20
Number of pages17
JournalBehavioural Brain Research
Volume176
Issue number1
DOIs
StatePublished - Jan 10 2007
Externally publishedYes

Fingerprint

Autistic Disorder
Reversal Learning
Phenotype
Water
Inbred Strains Mice
Aptitude
Task Performance and Analysis
Microarray Analysis
Interpersonal Relations
Anxiety
Communication
Mutation
Health
Genes

Keywords

  • Autism
  • Locomotion
  • Morris water maze
  • Reversal tasks
  • Sociability
  • Social approach
  • Social preference
  • T-maze

ASJC Scopus subject areas

  • Behavioral Neuroscience

Cite this

Moy, S. S., Nadler, J. J., Young, N. B., Perez, A., Holloway, L. P., Barbaro, R. P., ... Crawley, J. (2007). Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains. Behavioural Brain Research, 176(1), 4-20. https://doi.org/10.1016/j.bbr.2006.07.030

Mouse behavioral tasks relevant to autism : Phenotypes of 10 inbred strains. / Moy, Sheryl S.; Nadler, Jessica J.; Young, Nancy B.; Perez, Antonio; Holloway, L. Paige; Barbaro, Ryan P.; Barbaro, Justin R.; Wilson, Lindsay M.; Threadgill, David W.; Lauder, Jean M.; Magnuson, Terry R.; Crawley, Jacqueline.

In: Behavioural Brain Research, Vol. 176, No. 1, 10.01.2007, p. 4-20.

Research output: Contribution to journalArticle

Moy, SS, Nadler, JJ, Young, NB, Perez, A, Holloway, LP, Barbaro, RP, Barbaro, JR, Wilson, LM, Threadgill, DW, Lauder, JM, Magnuson, TR & Crawley, J 2007, 'Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains', Behavioural Brain Research, vol. 176, no. 1, pp. 4-20. https://doi.org/10.1016/j.bbr.2006.07.030
Moy SS, Nadler JJ, Young NB, Perez A, Holloway LP, Barbaro RP et al. Mouse behavioral tasks relevant to autism: Phenotypes of 10 inbred strains. Behavioural Brain Research. 2007 Jan 10;176(1):4-20. https://doi.org/10.1016/j.bbr.2006.07.030
Moy, Sheryl S. ; Nadler, Jessica J. ; Young, Nancy B. ; Perez, Antonio ; Holloway, L. Paige ; Barbaro, Ryan P. ; Barbaro, Justin R. ; Wilson, Lindsay M. ; Threadgill, David W. ; Lauder, Jean M. ; Magnuson, Terry R. ; Crawley, Jacqueline. / Mouse behavioral tasks relevant to autism : Phenotypes of 10 inbred strains. In: Behavioural Brain Research. 2007 ; Vol. 176, No. 1. pp. 4-20.
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