Motor sequencing deficits in schizophrenia: A comparison with Parkinson's disease

Edith V. Sullivan, Rosemary Fama, Paula K. Shear, Deborah Cahn-Weiner, Maria Stein, Robert B. Zipursky, Adolf Pfefferbaum

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Motor abnormalities occur in schizophrenia (SZ) and may arise from striatal dysfunction. This study examined whether the pattern of performance on simple and complex motor abilities in SZ was similar to that of patients with Parkinson's disease (PD). Quantitative tests of speeded movement and motor and cognitive sequencing were used to assess 25 SZ, 16 PD, and 84 normal controls (NCs). Sequencing performance was also examined with motor rigidity taken into account. Compared with the NC group, the SZ and PD groups were impaired on measures of motor rigidity and motor sequencing. With rigidity accounted for, the SZ group was significantly more impaired than the PD group on motor sequencing; cognitive and motor processes contributed to the motor deficit. Cognitive sequencing performance predicted motor sequencing performance in PD but not SZ. Although both SZ and PD resulted in significant motor and cognitive sequencing deficits, the pattern and correlates of these deficits differ, suggesting that the affected neural systems underlying motor deficits in SZ are different from those involved in PD.

Original languageEnglish (US)
Pages (from-to)342-350
Number of pages9
JournalNeuropsychology
Volume15
Issue number3
DOIs
StatePublished - Oct 1 2001
Externally publishedYes

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Parkinson Disease
Schizophrenia
Corpus Striatum
Aptitude
Parkinson's Disease
Sequencing
Control Groups

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Arts and Humanities (miscellaneous)

Cite this

Sullivan, E. V., Fama, R., Shear, P. K., Cahn-Weiner, D., Stein, M., Zipursky, R. B., & Pfefferbaum, A. (2001). Motor sequencing deficits in schizophrenia: A comparison with Parkinson's disease. Neuropsychology, 15(3), 342-350. https://doi.org/10.1037/0894-4105.15.3.342

Motor sequencing deficits in schizophrenia : A comparison with Parkinson's disease. / Sullivan, Edith V.; Fama, Rosemary; Shear, Paula K.; Cahn-Weiner, Deborah; Stein, Maria; Zipursky, Robert B.; Pfefferbaum, Adolf.

In: Neuropsychology, Vol. 15, No. 3, 01.10.2001, p. 342-350.

Research output: Contribution to journalArticle

Sullivan, EV, Fama, R, Shear, PK, Cahn-Weiner, D, Stein, M, Zipursky, RB & Pfefferbaum, A 2001, 'Motor sequencing deficits in schizophrenia: A comparison with Parkinson's disease', Neuropsychology, vol. 15, no. 3, pp. 342-350. https://doi.org/10.1037/0894-4105.15.3.342
Sullivan, Edith V. ; Fama, Rosemary ; Shear, Paula K. ; Cahn-Weiner, Deborah ; Stein, Maria ; Zipursky, Robert B. ; Pfefferbaum, Adolf. / Motor sequencing deficits in schizophrenia : A comparison with Parkinson's disease. In: Neuropsychology. 2001 ; Vol. 15, No. 3. pp. 342-350.
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