Motion of molecular motor ratcheted by internal fluctuations and protein friction

A. Mogilner, M. Mangel, R. J. Baskin

Research output: Contribution to journalArticle

37 Scopus citations

Abstract

We investigate theoretically a novel mechanism of transducing chemical energy into a directed force. A hypothetical motor protein is considered such that conformational changes induced by nucleotide binding and/or hydrolysis lead to asymmetric internal velocity fluctuations. We demonstrate that these fluctuations result in unidirectional motion if rectified by protein friction. The motor protein force-velocity relationship and other characteristics are computed based on analogy with known molecular motors.

Original languageEnglish (US)
Pages (from-to)297-306
Number of pages10
JournalPhysics Letters, Section A: General, Atomic and Solid State Physics
Volume237
Issue number4-5
StatePublished - Jan 12 1998

Keywords

  • Brownian ratchet
  • Molecular motors
  • Protein friction

ASJC Scopus subject areas

  • Physics and Astronomy(all)

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