Motion Corrected Cadence CPS Ultrasound for Quantifying Response to Vasoactive Drugs in a Rat Kidney Model

Rachel E. Pollard, Paul A. Dayton, Katherine D. Watson, Xiaowen Hu, Ismayil M. Guracar, Katherine W. Ferrara

Research output: Contribution to journalArticle

22 Scopus citations

Abstract

Objective: To establish the ability of contrast-enhanced motion corrected cadence pulse sequencing (CPS) to detect changes in renal blood flow induced by vasoactive substances in rats. Methods: Ultrasound contrast media was administered as a constant rate infusion into a phantom at a known rate and CPS data acquired. Rats were anesthetized and predrug CPS estimates of replenishment rate were made for the right kidney. Real-time motion correction was applied, and parametric images were generated from the CPS data. Group 1 rats (n = 7) were administered a vasodilator and group 2 rats (n = 3) were administered a vasoconstrictor. The CPS imaging of the kidney was repeated after ample time for drug effects to occur. Results: Contrast CPS accurately estimated flow velocity in the phantom model. In addition, CPS defined statistically significant differences between pre- and postdrug blood flow in the renal medulla (vasodilator, P < .01; vasoconstrictor, P < .0001) and cortex (vasoconstrictor, P < .0001). Conclusions: We conclude that motion-corrected CPS ultrasound provides real-time quantification of renal blood flow alterations and may prove useful for the assessment of blood flow in transplanted kidneys.

Original languageEnglish (US)
Pages (from-to)675-681
Number of pages7
JournalUrology
Volume74
Issue number3
DOIs
StatePublished - Sep 2009

ASJC Scopus subject areas

  • Urology

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