Mortality of one-week-old chickens during naturally occurring marek's disease virus infection

Francisco R Carvallo chaigneau, R. A A French, K. Gilbert-Marcheterre, G. Risatti, J. R R Dunn, F. Forster, M. Kiupel, J. A A Smyth

Research output: Contribution to journalArticle

10 Scopus citations

Abstract

Marek's disease (MD) is a disease of chickens that occurs worldwide and has serious economic consequences. MD can present as one of several forms, with the most commonly occurring forms being the lymphoproliferative diseases. Under experimental conditions, an early mortality syndrome has been recognized following infection by some but not all strains of MD virus (MDV). This is the first report of a confirmed case of mortality due to naturally occurring MDV infection in 1-week-old, nonvaccinated, chickens. Necrotizing lesions were observed in the bursa of Fabricius, lung, duodenum, jejunum, and proventriculus, and large intranuclear inclusion bodies were a striking feature in tissues with lesions in all birds. Immunohistochemical staining for the pp38 protein of MDV revealed abundant pp38 antigen in the affected tissues, confirming the presence of MDV within the lesions. PCR yielded an amplicon with 97% homology to the meq gene of MDV. No evidence of co-infection by either of the immunosuppressive agents chicken anemia virus and infectious bursal disease virus was detected.

Original languageEnglish (US)
Pages (from-to)993-998
Number of pages6
JournalVeterinary Pathology
Volume48
Issue number5
DOIs
StatePublished - Sep 2011
Externally publishedYes

Keywords

  • chickens
  • early mortality syndrome
  • Gallid-herpesvirus-2
  • Marek's disease

ASJC Scopus subject areas

  • veterinary(all)

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    Carvallo chaigneau, F. R., French, R. A. A., Gilbert-Marcheterre, K., Risatti, G., Dunn, J. R. R., Forster, F., Kiupel, M., & Smyth, J. A. A. (2011). Mortality of one-week-old chickens during naturally occurring marek's disease virus infection. Veterinary Pathology, 48(5), 993-998. https://doi.org/10.1177/0300985810395727