Morphometry for early monitoring of treatment response in rheumatoid arthritis

Anand A. Joshi, Richard M. Leahy, Ramsey D Badawi, Abhijit Chaudhari

Research output: Chapter in Book/Report/Conference proceedingConference contribution

3 Scopus citations

Abstract

New aggressive therapeutic options have recently become available to treat inflammatory arthritis (IA) and rheumatoid arthritis in particular. These treatments not only control joint destruction, they may also aid in new bone formation at sites of eroded bone. Separation of non-responders from responders to these treatments, is critical, and is known to lead to reduced disease burden, toxicity, side-effects and overall cost. The bones of the wrist are early targets of IA and are known to show response to therapy early. In this paper, we develop a method to quantify point-wise erosive changes of wrist bones in IA patients undergoing treatment. The method employs 3D registration-based morphometric analysis. Our results indicate that the proposed method has potential to improve sensitivity to small, early changes in bone erosion status. This study has potential to provide new imaging biomarkers to be used in clinical trials evaluating the efficacy of new arthritis drugs.

Original languageEnglish (US)
Title of host publicationProceedings - International Symposium on Biomedical Imaging
Pages121-124
Number of pages4
DOIs
StatePublished - 2013
Event2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013 - San Francisco, CA, United States
Duration: Apr 7 2013Apr 11 2013

Other

Other2013 IEEE 10th International Symposium on Biomedical Imaging: From Nano to Macro, ISBI 2013
CountryUnited States
CitySan Francisco, CA
Period4/7/134/11/13

ASJC Scopus subject areas

  • Biomedical Engineering
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Morphometry for early monitoring of treatment response in rheumatoid arthritis'. Together they form a unique fingerprint.

Cite this