Morphometric characteristics of cells in the alveolar region of mammalian lungs

J. D. Crapo, S. L. Young, E. K. Fram, Kent E Pinkerton, B. E. Barry, R. O. Crapo

Research output: Contribution to journalArticle

183 Citations (Scopus)

Abstract

Morphometric procedures have been used to study the characteristics of cells in the alveolar region of the lungs of rats, dogs, baboons, and humans. Compared with the other species, human lungs were found to contain greater numbers of macrophages and to have larger alveolar type II, endothelial, and interstitial cells. The thickness of the interstitium and the pulmonary capillary endothelium were also significantly greater in the human lungs. These differences in human lung anatomy may be due to increased exposure to airborne pollutants and to tobacco smoke. Despite the above differences and the fact that there are large variations in size and functional characteristics of the lungs of these mammals, an overall striking similarity in characteristics of individual lung cells was found. The distribution of cells in alveolar tissue was remarkably constant between species as was the average volume and surface area of most cell types. Computer-aided three-dimensional reconstruction techniques were used to determine the spatial relationship or organelles in individual alveolar type II cells from rats. A three-dimensional reconstruction of cells permits quantification of number, size, surface area, and volume of subcellular organelles and correlations of their three-dimensional spatial relationships.

Original languageEnglish (US)
JournalAmerican Review of Respiratory Disease
Volume128
Issue number2 II Suppl.
StatePublished - 1983
Externally publishedYes

Fingerprint

Alveolar Epithelial Cells
Lung
Organelle Size
Papio
Vascular Endothelium
Smoke
Organelles
Tobacco
Mammals
Anatomy
Endothelial Cells
Macrophages
Dogs

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Crapo, J. D., Young, S. L., Fram, E. K., Pinkerton, K. E., Barry, B. E., & Crapo, R. O. (1983). Morphometric characteristics of cells in the alveolar region of mammalian lungs. American Review of Respiratory Disease, 128(2 II Suppl.).

Morphometric characteristics of cells in the alveolar region of mammalian lungs. / Crapo, J. D.; Young, S. L.; Fram, E. K.; Pinkerton, Kent E; Barry, B. E.; Crapo, R. O.

In: American Review of Respiratory Disease, Vol. 128, No. 2 II Suppl., 1983.

Research output: Contribution to journalArticle

Crapo, JD, Young, SL, Fram, EK, Pinkerton, KE, Barry, BE & Crapo, RO 1983, 'Morphometric characteristics of cells in the alveolar region of mammalian lungs', American Review of Respiratory Disease, vol. 128, no. 2 II Suppl..
Crapo, J. D. ; Young, S. L. ; Fram, E. K. ; Pinkerton, Kent E ; Barry, B. E. ; Crapo, R. O. / Morphometric characteristics of cells in the alveolar region of mammalian lungs. In: American Review of Respiratory Disease. 1983 ; Vol. 128, No. 2 II Suppl.
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