Morphometric analysis of predictors of cervical Syrinx formation in the setting of Chiari I malformation

Kyle G. Halvorson, Ryan T. Kellogg, Krista N. Keachie, Gerald A. Grant, Carrie R. Muh, Ben Waldau

Research output: Contribution to journalArticle

5 Scopus citations

Abstract

Background/Aims: We performed a morphometric analysis of Chiari I malformations to look for predictors of cervical syrinx formation. Methods: Eighteen patients with Chiari I malformation and associated cervical syrinx and 16 patients with Chiari I malformation without associated cervical syrinx were included in the study. Chiari I size was obtained from the radiology report; foramen magnum diameter, cerebellar volume, posterior fossa volume and intracranial volume were calculated using OsiriX software, and average measurements were compared between the two groups. Results and Conclusion: Patients with Chiari I with syrinx had an average tonsillar descent of 13.03 ± 5.31 mm compared to 9.25 ± 3.31 mm in the Chiari I without syrinx group (p < 0.05). Patients with Chiari I and syrinx also showed increased cerebellar crowding with a higher cerebellar volume to posterior fossa volume ratio; however, this difference was not significant (0.83 vs. 0.81; p = 0.1872). No difference between groups was found in posterior fossa volume, intracranial volume and foramen magnum diameter. Therefore, only Chiari I size based on the extent of tonsillar herniation was found to be a determinant of cervical syrinx formation.

Original languageEnglish (US)
Pages (from-to)137-141
Number of pages5
JournalPediatric Neurosurgery
Volume51
Issue number3
DOIs
StatePublished - Apr 1 2016

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Keywords

  • Cerebellar volume
  • Chiari I malformation
  • Intracranial volume
  • Posterior fossa volume
  • Syrinx

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Clinical Neurology
  • Surgery

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