Morphological plasticity in an infant monkey model of temporal lobe epilepsy

H. Jürgen Wenzel, Donald E. Born, Mark F. Dubach, Virginia M. Gunderson, Kenneth R. Maravilla, Carol A. Robbins, Partrizia Szot, Danielle Zierath, Philip A Schwartzkroin

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Purpose/Methods: Seizures in early life are thought to contribute to the development of human temporal lobe epilepsy. To examine the consequences of early seizures, we elicited status epilepticus in immature, 5.5- to 7.0-month-old pigtailed macaques by unilateral microinfusion of bicuculline methiodide into the entorhinal cortex. Results: This report focuses on neuropathological changes in the hippocampus. Bicuculline infusion consistently elicited limbic-like seizures with prolonged, relatively localized electrographic activity. Magnetic resonance imaging revealed enhanced signal intensity in the ipsilateral hippocampus after seizures; in some cases, there was also progressive hippocampal atrophy. Histological changes were variable; in two of five monkeys, there was significant hippocampal neuron loss, gliosis, granule cell dispersion, and mossy fiber reorganization. Conclusions: The histopathological findings and associated magnetic resonance imaging abnormalities after bicuculline-induced status epilepticus in infant monkeys mimic common aspects of human temporal lobe epilepsy.

Original languageEnglish (US)
JournalEpilepsia
Volume41
Issue numberSUPPL. 6
StatePublished - 2000
Externally publishedYes

Fingerprint

Temporal Lobe Epilepsy
Haplorhini
Seizures
Bicuculline
Status Epilepticus
Hippocampus
Magnetic Resonance Imaging
Entorhinal Cortex
Gliosis
Macaca
Human Development
Atrophy
Neurons

Keywords

  • Epileptogenesis
  • High-resolution MRI
  • Hippocampus
  • Seizure-induced neuronal damage
  • Sprouting

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)

Cite this

Wenzel, H. J., Born, D. E., Dubach, M. F., Gunderson, V. M., Maravilla, K. R., Robbins, C. A., ... Schwartzkroin, P. A. (2000). Morphological plasticity in an infant monkey model of temporal lobe epilepsy. Epilepsia, 41(SUPPL. 6).

Morphological plasticity in an infant monkey model of temporal lobe epilepsy. / Wenzel, H. Jürgen; Born, Donald E.; Dubach, Mark F.; Gunderson, Virginia M.; Maravilla, Kenneth R.; Robbins, Carol A.; Szot, Partrizia; Zierath, Danielle; Schwartzkroin, Philip A.

In: Epilepsia, Vol. 41, No. SUPPL. 6, 2000.

Research output: Contribution to journalArticle

Wenzel, HJ, Born, DE, Dubach, MF, Gunderson, VM, Maravilla, KR, Robbins, CA, Szot, P, Zierath, D & Schwartzkroin, PA 2000, 'Morphological plasticity in an infant monkey model of temporal lobe epilepsy', Epilepsia, vol. 41, no. SUPPL. 6.
Wenzel HJ, Born DE, Dubach MF, Gunderson VM, Maravilla KR, Robbins CA et al. Morphological plasticity in an infant monkey model of temporal lobe epilepsy. Epilepsia. 2000;41(SUPPL. 6).
Wenzel, H. Jürgen ; Born, Donald E. ; Dubach, Mark F. ; Gunderson, Virginia M. ; Maravilla, Kenneth R. ; Robbins, Carol A. ; Szot, Partrizia ; Zierath, Danielle ; Schwartzkroin, Philip A. / Morphological plasticity in an infant monkey model of temporal lobe epilepsy. In: Epilepsia. 2000 ; Vol. 41, No. SUPPL. 6.
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