Morphologic and immunopathologic studies on rhesus monkeys with Mycobacterium Mycobacterium avium infection

Bennie Osburn, C. A. Holmberg, T. G. Terrell

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In previous reports cases of avian tuberculosis in monkeys have been described. In this article changes in serum, lymphocyte response, morphologic lesions in lymph nodes and viscera are reported. Morphologic studies of the intestine included light, scanning and transmission electron microscopy. Lymph node biopsies taken over a 5 mth period revealed initially a predominant plasma cell infiltration to one with relative lymphoid depletion at the time of death. Serum β and γ globulin levels complimented morphologic changes in the respect that 3.5 g of γ globulin were observed in serum from animals with lymph nodes diffusely infiltrated with plasma cells. Lymphocytes from animals with elevated β and γ globulin values had depressed lymphocyte stimulation responses to phytohemagglutinin (PHA) and low rosetting values with sheep red blood cells. Morphologic changes of the intestinal tract included villous atrophy, infiltration of the lamina propria with macrophages heavily laden with acid fast organisms, and microgranulomas of the submucosa and serosal surface as observed by light and scanning electron microscopy. Results of this study suggest that avian tuberculosis is associated with an immunoproliferative disorder.

Original languageEnglish (US)
JournalAmerican Journal of Pathology
Volume78
Issue number1
StatePublished - Jan 1 1975

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Mycobacterium avium
Mycobacterium Infections
Avian Tuberculosis
Mycobacterium
Macaca mulatta
Lymph Nodes
Globulins
Plasma Cells
Immunoproliferative Disorders
Lymphocytes
Light
Serum Globulins
Scanning Transmission Electron Microscopy
Viscera
Phytohemagglutinins
Lymphocyte Activation
Serum
Electron Scanning Microscopy
Atrophy
Intestines

ASJC Scopus subject areas

  • Pathology and Forensic Medicine

Cite this

Morphologic and immunopathologic studies on rhesus monkeys with Mycobacterium Mycobacterium avium infection. / Osburn, Bennie; Holmberg, C. A.; Terrell, T. G.

In: American Journal of Pathology, Vol. 78, No. 1, 01.01.1975.

Research output: Contribution to journalArticle

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